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24(S)-hydroxy Cholesterol

LXRα和LXRβ核受体激活剂，24(S)-Hydroxycholesterol (24S-OHC) 是脑胆固醇的主要代谢物，对维持脑内胆固醇的稳态起主要作用。24(S)-Hydroxycholesterol (24S-OHC) 是非常有效的内源性的 LXR 的激动剂，在大脑和循环系统中含量高。24(S)-Hydroxycholesterol (24S-OHC) 是有效直接的、选择性的NMDARs 的阳性变构调节剂，其机制不会与其它异构调节因子重叠。

目录号: PC15339 纯度: ≥98%

CAS No. :474-73-7

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中文名称

24(S)-hydroxy Cholesterol

中文别名

(3Β,24S)-胆甾-5-烯-3,24-二醇;24-S-羟基胆固醇

英文名称

24(S)-hydroxy Cholesterol

英文别名

Cholest-5-ene-3,24-diol,(3b,24S)-;cholest-5-ene-3β,24(S)-diol;(3β,24S)-Cholest-5-ene-3,24-diol;24(S)-hydroxy Cholesterol;(24S)-24-hydroxycholesterol;24-hydroxycholesterol;24S-hydroxycholesterol;24S-hydroxy-cholesterol;24S-OHC;Cerebrosterol;CHEBI:34310;cholest-5-en-3beta,24S-diol;Cholest-5-ene-3,24-diol;cholest-5-ene-3b,24a-diol;5-Cholesten-3β,24(S)-diol;Cerebrosterin;Cholest-5-ene-3β,24-diol;24-hydroxycholest-5-en-3-ol;5-cholestene-3β,24-diol;5-cholestene-3β,24-diol; 24-hydroxycholest-5-en-3-ol;24(S)-Hydroxycholesterol

Cas No.

474-73-7

分子式

C₂₇H₄₆O₂

分子量

402.65

包装储存

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators.

性状

Solid

IC50 & Target[1][2]

NMDA Receptor

Human Endogenous Metabolite

运输条件

Room temperature or refrigerated transportation.

储存方式