Schisandrin A|7432-28-2|(五味子醇甲; Schizandrin; Schizandrol; Schizandrol-A)-陌孚医药/Medlife

您当前的位置：

Schisandrin A (Synonyms: 五味子醇甲; Schizandrin; Schizandrol; Schizandrol-A)

目录号: PC13543 纯度: ≥98%

CAS No. :7432-28-2

商品编号	规格	价格	会员价	是否有货	数量
PC13543-20mg	20mg	¥141.25	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称

Schisandrin A

中文别名

五味子素;五味子醇甲;Schisandrol A 五味子醇甲标准品;WAKO197-13551北五味子素;五味子 USP标准品;五味子醇甲(标准品);五味子醇甲,Gomisin A,植物提取物,标准品,对照品;五味子醇甲、五味子素;五味子醇甲Schisandrin;五味子醇甲对照品;五味子素(五味子醇 A)(P);五味子素标准品;五味子提取物;五味子总素;分析对照品;五味子醇 A

英文名称

Schisandrin A

英文别名

schizandrin;Schisandrol A;SCHISANDRIN;SCHISANDRIN (SCHISANDROL A);SCHISANDRIN(SCHISANDROL A)(P) PrintBack;Schizandrol;Schizandrol A;Schisandrol A;Schisadrol A;Schisandrol;schizandra;Schizandrin std.;Schizandrol-A;Wuweizi alcohol-A;Wuweizichun-A;(+)-Schizandrin;Schisandrine;Wuweizi alcohol A;Wuweizichun A;5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol;[ "" ];hexamethoxy(dimethyl)[?]ol;(+)-Isoschizandrin

Cas No.

7432-28-2

分子式

C₂₄H₃₂O₇

分子量

432.51

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats.

性状

Solid

体外研究(In Vitro)

Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production, iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells.
Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages.
Schisandrin inhibits the SK-HEP-1, SNU-638, and T47D cells proliferation, with IC₅₀s of 42.0, 53.1, and 40.0 μM, respectively.
Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	RAW 264.7 macrophages
Concentration:	12.5, 25, 50, 100 μM
Incubation Time:	Pretreated for 2 h and then incubated with LPS (1 μg/mL) for 18 h
Result:	Markedly decreased iNOS protein expression a dose-dependent manner. Significantly inhibited COX-2 protein expression.

体内研究(In Vivo)

Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces the carrageenan-induced paw edema of mice.
Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses the Scopolamine-induced impairment of spatial memory and passive avoidance response, and enhances tremors induced by Oxotremorine in rats.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR mice (4-weeks) were treated with λ-carrageenan by intraperitoneal injection into the right hind paw
Dosage:	100, 200 mg/kg
Administration:	A single i.p.
Result:	Inhibited paw edema by 33.43 % (100 mg/kg) and 57.38 % (200 mg/kg) at 3 h.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

结构分类

来源

参考文献

[1]. Guo LY, et, al. Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. Eur J Pharmacol. 2008 Sep 4;591(1-3):293-9. [Information]

[2]. Egashira N, et, al. Schizandrin reverses memory impairment in rats. Phytother Res. 2008 Jan;22(1):49-52. [Information]

[3]. Min HY, et, al. Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. Bioorg Med Chem Lett. 2008 Jan 15;18(2):523-6. [Information]

[4]. Zhang ZL, et, al. Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation. Breast Cancer. 2018 Mar;25(2):233-242. [Information]

溶解度数据

体外研究:

DMSO : 1 mg/mL (2.31 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3121 mL	11.5604 mL	23.1209 mL
5 mM	---	---	---
10 mM	---	---	---

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 0.28 mg/mL (0.65 mM); Clear solution

此方案可获得 ≥ 0.28 mg/mL (0.65 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 2.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH?O 中，得到澄清透明的生理盐水溶液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation