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Triacsin C

酰基辅酶A合成酶抑制剂，Triacsin C (WS 1228A) 来自金黄色链霉菌 (Streptomyces aureofaciens) ，是一种天然细胞内长链酰基辅酶A合成酶 (ACSL) 抑制剂。Triacsin C 通过抑制 ACSL 来抑制 TAG 积聚成脂滴 (LD) 。Triacsin C 对轮状病毒复制非常有效。

目录号: PC15199 纯度: ≥98%

CAS No. :76896-80-5

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中文名称

Triacsin C

中文别名

三氮菌素 C

英文名称

Triacsin C

英文别名

2,4,7-Undecatrienal,nitrosohydrazone, (2E,4E,7E)-;Triacsin C;1-hydroxy-3-(E,E,E,-2',4',7'-undecatrienylidine)triazene;2,4,7-Undecatrienal;2E,4E,7E-UNDECATRIENE-1-TRIAZENE;2E,4E,7E-undecatriene-1-triazine;Antibiotic WS-1228A;Galloflavin;triacsin c from streptomyces sp.;Triacsincapprox.;WS1228A;2,4,7-Undecatrienal nitrosohydrazone;(?,E,E,E)-2,4,7-Undecatrienal nitrosohydrazone;FR 900190;WS 1228A

Cas No.

76896-80-5

分子式

C₁₁H₁₇N₃O

分子量

207.27

包装储存

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity. Triacsin C is found to be highly effective against rotavirus replication.

性状

Solid

IC50 & Target[1][2]

IC50: 3.70 μM (CpACS1), 2.32 μM (CpACS2)

体外研究(In Vitro)

Triacsin C (0-16 μM; 41 h) inhibits parasite fatty acyl-coenzyme A synthetases, and reduces CpACS1 and CpACS2 enzymes activities with IC₅₀s of 3.70 μM and 2.32 μM, respectively, with K_i values of 595 nM and 106 nM, respectively.
Triacsin C (0-16 μM; 41 h) shows anti-parasitic and inhibits Cryptosporidium parvum with an IC₅₀ value of 136 nM.
Triacsin C (0, 0.25, 0.5 μM; 30 min) has no effect on parasite invasion.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Triacsin C (8-15 mg/kg/d; p.o.; 1 week) shows anticryptosporidial efficacy and improves Cryptosporidium parvum infection by targeting parasite fatty acyl-coenzyme A synthetases.
Triacsin C (10 mg/kg/d; p.o.; 2 months) exhibits anti-atherosclerotic activity in aortic atherosclerosis LDLR mice.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Cryptosporidium-infected interleukin knockout mice
Dosage:	8-15 mg/kg/d
Administration:	Oral gavage; 1 week
Result:	Reduced parasite oocyst production up to 88.1% with no apparent toxicity.

Animal Model:	Low-density lipoprotein receptor-knockout (LDLR) mice (C57BL/6 background)
Dosage:	10 mg/kg/d
Administration:	Oral gavage; 2 months
Result:	Increased plasma TG, plasma cholesterol, plasma free fatty acid, and plasma glucose concentration. Improved the growth of aortic atherosclerosis mice, increased the body weight of mince.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

结构分类

Ketones, Aldehydes, Acids

参考文献

[1]. Dechandt CRP, et al. Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. J Bioenerg Biomembr. 2017 Oct;49(5):399-411. [Information]

[2]. Kim Y, et al. Novel triacsin C analogs as potential antivirals against rotavirus infections. Eur J Med Chem. 2012 Apr;50:311-8. [Information]

[3]. Guo F, et al. Amelioration of Cryptosporidium parvum infection 体外研究 and in vivo by targeting parasite fatty acyl-coenzyme A synthetases. J Infect Dis. 2014 Apr 15;209(8):1279-87. [Information]

[4]. Matsuda D, et al. Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor. J Antibiot (Tokyo). 2008 May;61(5):318-21. [Information]

溶解度数据

体外研究:

DMSO : 5 mg/mL (24.12 mM; Need ultrasonic and warming)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.8246 mL	24.1231 mL	48.2462 mL
5 mM	0.9649 mL	4.8246 mL	9.6493 mL
10 mM	0.4825 mL	2.4123 mL	4.8246 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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