Mequitazine|29216-28-2|(美喹他嗪; LM-209)-陌孚医药/Medlife

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Mequitazine (Synonyms: 美喹他嗪; LM-209)

目录号: PC19153 纯度: ≥98%

CAS No. :29216-28-2

商品编号	规格	价格	会员价	是否有货	数量
PC19153-5mg	5mg	¥840.00	请登录
PC19153-10mg	10mg	¥1261.00	请登录

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中文名称

Mequitazine

中文别名

美喹他嗪;10-(1-氮杂双环[2.2.2]辛烷-3-基甲基)-10H-吩噻嗪;美喹他嗪标准品;他克莫司;甲喹吩嗪;10-(奎宁环-3-基甲基)-10H-吩噻嗪

英文名称

Mequitazine

英文别名

Mequitazine;C20H22N2S;10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine;10-(3-quinuclidinylmethyl) phenothiazine;LM 209;NSC 303612;10-(Quinuclidin-3-ylmethyl)-10H-phenothiazine;Metaplexan;Primalan;Virginan;Mircol;Instotal;Vigigan;Mequitazina [Spanish];Mequitazina;Mequitazinum [INN-Latin];Mequitazina [INN-Spanish];(R)-(+)-Mequitazine;10-(3-Quinuclidinylmethyl)phenothiazine;Mequitazine [INN:BAN:DCF:JAN];Phenothiazine, 10-(3-quinuclidinylmethyl)-;10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine;NSC303612;10-(

Cas No.

29216-28-2

分子式

C₂₀H₂₂N₂S

分子量

322.47

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Mequitazine is a potent, and long-acting histamine H₁ antagonist.

性状

Solid

体外研究(In Vitro)

Mequitazine is a potent H₁-receptors selective antihistaminic drug widely studied and used for allergic disorders such as hay fever and urticaria. Mequitazine demonstrates significant bactericidal effects against all the tested clinical isolates including Ps. aeruginosa. Its effect against the Gram-positive isolates is more pronounced.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Mequitazine and clemizole antagonize the effect of histamine in guinea-pig ileum competitively. Mequitazine at 10 produces a parallel shift of the dose-response curve to acetylcholine in the rat duodenum. Mequitazine at highest concentration shows anticholinergic activity. Mequitazine inhibits contractile responses to KCl, phenylephrine (PE), 5-hydroxytryptamine (5-HT), and Ca in rat aorta.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. Gonnot V, et al. Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate. Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1300-2. [Information]

[2]. El-Nakeeb MA, et a. 体外研究 antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates. Braz J Microbiol. 2011 Jul;42(3):980-91. [Information]

[3]. Martinez-Mir I, et al. Antihistaminic and anticholinergic activities of mequitazine in comparison with clemizole. J Pharm Pharmacol. 1988 Sep;40(9):655-6. [Information]

[4]. Satake N, et al. Possible mechanisms of vasoinhibitory effects of mequitazine, an antiallergic agent, on the contractions of isolated rat aorta induced by K+, phenylephrine, 5-hydroxytryptamine, and Ca2+. J Cardiovasc Pharmacol. 1994 Apr;23(4):669-73. [Information]

溶解度数据

体外研究:

DMSO : 16 mg/mL (49.62 mM; Need ultrasonic and warming)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1011 mL	15.5053 mL	31.0106 mL
5 mM	0.6202 mL	3.1011 mL	6.2021 mL
10 mM	0.3101 mL	1.5505 mL	3.1011 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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