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A 77636 hydrochloride

目录号: PC14532 纯度: ≥98%

D1样多巴胺受体激动剂，A-77636 is a dopamine D1 receptor agonist (Ki = 40 nM).

CAS No. :145307-34-2

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中文名称	A 77636 hydrochloride
中文别名	A 77636盐酸盐
英文名称	A 77636 hydrochloride
英文别名	1H-2-Benzopyran-5,6-diol,1-(aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-, hydrochloride(1:1), (1R,3S)-;1H-2-Benzopyran-5,6-diol,1-(aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-, hydrochl...;A 77636 hydrochloride;A-77636 hydrochloride hydrate;(1R,3S)-3-(1'-adamantyl)-1-aminomethyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride;(1R-cis)-1-(AMinoMethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diolhydrochloride;A 77636;A-77636 hydrate hydrochloride;(1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride;(-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE;(?)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate;(-)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrate hydrochloride;(1R)-cis-1-Aminomethyl-3,4-dihydro-3-tricyclo[3.3.1.13.7]dec-1-yl-[1-h]-2-benzopyran-5,6-diolhydrochloride
Cas No.	145307-34-2
分子式	C₂₀H₂₇NO₃^.HCl
分子量	365.89
包装储存	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pK_i=7.40; K_i=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor.

性状

Solid

体内研究(In Vivo)

A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake, due principally to a reduction in meal size and duration.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male hooded rat
Dosage:	0.1, 0.3 and 1.0 mg/kg
Administration:	S.c.
Result:	Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration.