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Bethanechol chloride

(Synonyms: 氯贝胆碱; Carbamyl-β-methylcholine chloride)

目录号: PC14227 纯度: ≥98%

毒蕈碱受体激动剂，Bethanechol氯化物是毒蕈碱型受体（mAChR）选择性激动剂，而对烟碱受体无活性。

CAS No. :590-63-6

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PC14227-10mM (in 1mL H2O)	10mM (in 1mL H2O)	¥637.00	请登录

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中文名称	Bethanechol chloride
中文别名	比赛可灵;氯贝胆碱;氯化氨基甲酰-Β-甲基胆碱;2-[(氨基甲酰)氧基]-N,N,N-三甲基-1-丙铵氯化物;氯化氨甲酰甲胆碱;乙酰甲喹(痢菌净);氨甲酰甲胆碱-D7氯化物;氯化铵甲酰甲胆碱;乙酰甲喹;Bethanechol Chloride 氯贝胆碱;胆碱-D6氯化物;氯贝胆碱 USP标准品;氯贝胆碱（拟胆碱药）;氯化氨甲酰甲胆碱(比赛可灵);四甲基乙二胺;乌拉胆碱;(2-氨基甲酰氧基丙基)三甲基氯化铵;氨基甲酰基-β-甲基氯化胆碱;抗胆碱药
英文名称	Bethanechol chloride
英文别名	Bethanechol;(2-hydroxypropyl)trimethylammoniumchloridecarbamate;2-((aminocarbonyl)oxy)-n,n,n-trimethyl-1-propanaminiuchloride;2-[(aminocarbonyl)oxy]-n,n,n-trimethyl-1-propanaminiuchloride;ammonium,(2-hydroxypropyl)trimethyl-,chloride,carbamate;beta-methylcholinechlorideurethan;bethainecholinechloride;carbaminoyl,beta-methylcholinechloride;carbamyl-b-methylcholinechloride*crystalline;Bethanechol Chloride;2-carbamoyloxypropyl(trimethyl)azanium,chloride;Carbamyl-β-methylcholine chloride;carbamyl-B-methylcholine chloridecrystalline;(2-Carbamoyloxy-propyl)-trimethyl-ammonium,Chlorid;(2-carbamoyloxy-propyl)-trimethyl-ammonium,chloride;2-carbamyloxy-1-(N,N,N-trimethyl)-propylammonium chloride;Besacholine;Mechotane;Mechothane;Mecothane;methylcarbachol chloride;Mictone;Myocholine;Urecholine;Urecholine chloride;Uro-Carb;(2-Carbamoyloxypropyl)trimethylammonium Chloride;2-[(Aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium chloride;2-Carbamoyloxypropyltrimethylammonium chloride;Myotonachol;Myotonine;Mictrol;Duvoid;Muscaran;Carbamylmethylcholine chloride;Carbamyl-beta-methylcholine chloride;Bethaine choline chloride;Bethanechol (chloride);Trimethyl(2-carbamoyloxypropyl)ammonium chloride;(2-Hydroxypropyl)trimethylammonium chloride carbamate;Myotonine chloride;beta-Methylcholine chloride urethan
Cas No.	590-63-6
分子式	C₇H₁₇ClN₂O₂
分子量	196.68
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system.

性状

Solid

IC50 & Target[1][2]

mAChR

体外研究(In Vitro)

Bethanechol chloride (0.3-300 μM) significantly reduces ileal pacemaker potentials.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Bethanechol (2-12 mg/kg; i.p.) induces drinking and increases urine output of rats in a dose-dependent fashion.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female rats of the Blue Spruce Farms (Sprague-Dawley) (280-330 g)
Dosage:	2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg
Administration:	Intraperitoneal injection
Result:	Increased water intake during the first hr in a dose-dependent fashion up to the highest dose administered (12 mg/kg).

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Inderbir S. Padda, et al. Bethanechol. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.

[2]. Julia Yuen Hang Liu, et al. Acetylcholine exerts inhibitory and excitatory actions on mouse ileal pacemaker activity: role of muscarinic versus nicotinic receptors. Am J Physiol Gastrointest Liver Physiol. 2020 Jul 1;319(1):G97-G107. [Information]

[3]. M J Fregly, et al. Bethanechol-induced water intake in rats: possible mechanisms of induction. Pharmacol Biochem Behav. 1982 Oct;17(4):727-32. [Information]

溶解度数据

体外研究:

H₂O : ≥ 50 mg/mL (254.22 mM)

DMSO : 11.11 mg/mL (56.49 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.0844 mL	25.4220 mL	50.8440 mL
5 mM	1.0169 mL	5.0844 mL	10.1688 mL
10 mM	0.5084 mL	2.5422 mL	5.0844 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 100 mg/mL (508.44 mM); Clear solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Bethanechol chloride

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