4-Aminobutyric acid.|56-12-2|(γ-氨基丁酸; 4-Aminobutyric acid)-陌孚医药/Medlife

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4-Aminobutyric acid. (Synonyms: γ-氨基丁酸; 4-Aminobutyric acid)

目录号: PC15411 纯度: 99%

CAS No. :56-12-2

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中文名称

4-Aminobutyric acid.

中文别名

γ-氨基丁酸;gamma-氨基丁酸;4-氨基丁酸;氨酷酸;4(GAMMA)-氨基丁酸；氨酪酸;氨酪酸;伽马氨基丁酸;丁氨酸;4-氨基丁酸；Γ-氨基丁酸;Γ-丁胺酸;四氨基丁酸;r-氨基丁酸;4-Aminobutyric Acid 4-氨基丁酸;4-氨基丁酸(GABA);4-胺基丁酸;y-氨基丁酸;γ-aminobutyric acid； γ-氨基丁酸标准品;γ-氨基丁酸(GABA);γ-氨基丁酸标准品;γ－氨酪酸;氨基丁酸;并[1,2 -13C2 ] -4 - 氨基丁酸标准品;伽玛氨基丁酸;4-氨基丁酸；γ-Aminobutyric acid;4-氨基丁酸；氨酪酸;4-氨基正丁酸;哌啶酸;γ-氨基丁酸 ;γ-氨基丁酸，GABA,4-氨基丁酸

英文名称

4-Aminobutyric acid

英文别名

4-Aminobutyric acid;4-AMINOBUTANOIC ACID;4-AMINO-N-BUTYRIC ACID;ALPHA-AMINOBUTANOIC ACID;AMINOBUTYRIC-4 ACID;AMINOBUTYRIC ACID, 4-;AURORA KA-1053;DL-GAMMA-AMINO-N-BUTYRIC ACID;GABA;GAMMA-AMINOBUTYRIC ACID;GAMMA-AMINO-N-BUTYRIC ACID;H-4-AMINOBUTYRIC ACID;H-ABU(4)-OH;H-ABU(GAMMA)-OH;H-GABA-OH;H-GAMMA-ABU-OH;NH2-(CH2)3-COOH;PIPERIDIC ACID;PIPERIDINIC ACID;RARECHEM EM WB 0019;AMINOBUTYRIC ACID, gamma-(GABA)(P);AMINOBUTYRIC ACID, gamma-(GABA)(RG);γ-Aminobutyric acid;Gamma Aminobutyric Acid (GABA);γ-AMinobutanoic acid;3-Carboxypropylamine;γ－aminobutyric acid (GABA);Aminalon;Gammalon;Gaballon;Mielogen;butanoic acid, 4-amino-;Mielomade;Gammalone;Gamarex;Gammasol;Gammar;Reanal;Immu-G;gamma-Aminobutanoic acid;Butyric acid, 4-amino-;Gammagee;Gamastan;Gamulin;4-aminobutyrate;omega-Aminobutyric acid;.gamma.-Aminobutyric acid;gamma-Aminobuttersaeure;4-aminobutanoate;4-amino-butanoic acid;gamma-Amino butyric a

Cas No.

56-12-2

分子式

C₄H₉NO₂

分子量

103.12

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABA_A receptors) and metabotropic receptors (GABA_B receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system.

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

Microbial Metabolite

体外研究(In Vitro)

γ-Aminobutyric acid (30 μM) depolarizes cortical progenitor cells (E16 cells), results an inward current in ventricular zone (VZ) cells, and induces DNA synthesis inhibition, with half-maximal response concentration of 5 μM.
Cortical plate (cp) neurons expresses glutamic acid decarboxylase (GAD), γ-Aminobutyric acid (1-5 μM; 18 h) stimulates the motility and arrests the migration of cp cells, while the chemotropic signal is involved G-protein activation.
γ-Aminobutyric acid activates GABA _A receptors, causing cell cycle arrest in S phase and limiting growth.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay

Cell Line:	Cortical plate (cp) neurons
Concentration:	1-5 μM
Incubation Time:	18 hours
Result:	Promoted motility via G-protein activation and arrested attractantinduced migration via GABAA receptor-mediated depolarization.

体内研究(In Vivo)

γ-Aminobutyric acid (33.95, 102.25, 306.75 mg/kg; p.o.; single dose) can enhance the sleep of mice.
γ-Aminobutyric acid (1, 2, 4 mg/kg/d; p.o.; 30 d) alleviates anxiety and restored food utilization rate in rats, with impairment induced by Di(2-ethylhexyl) phthalate (DEHP) exposure.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Pathogens free (SPF) Bagg’s albino (Balb/c) mice (18–20 g, 8 weeks old)
Dosage:	33.95, 102.25, 306.75 mg/kg
Administration:	Oral gavage; single dose; 20 mL/kg administration; measured in an hour
Result:	Prolonged the sleep duration, increased sleep rate, and shorten the sleep latency more effectively.

Animal Model:	Sprague-Dawley rat indued by DEHP (HY-B1945) (500 mg/kg)
Dosage:	1, 2, 4 mg/kg
Administration:	Oral gavage; combined administration; for 30 consecutive days
Result:	Reduced the levels of nitric oxide and nitric oxide synthase in rats treated with DEHP.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

结构分类

Ketones, Aldehydes, Acids

来源

mammalian central nervous system

参考文献

[1]. Chen S, et al. Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets. Food Funct. 2019 Jan 2. [Information]

[2]. Okada R, et al. Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobe. J Comp Neurol. 2009 May 1;514(1):74-91. [Information]

溶解度数据

体外研究:

H₂O : 50 mg/mL (484.87 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	9.6974 mL	48.4872 mL	96.9744 mL
5 mM	1.9395 mL	9.6974 mL	19.3949 mL
10 mM	0.9697 mL	4.8487 mL	9.6974 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 100 mg/mL (969.74 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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