苯甲酰胺;苯酰胺;苯甲酰胺 BENZAMIDE;苯甲酰胺(区域精制法精制,熔段数:20);Benzamide 苯甲酰胺;Benzamide Zone Refined (number of passes:20) 苯甲酰胺(区域精制法精制,熔段数:20);苯甲酰胺 标准品;苯甲酰胺,Benzamide,CP;苯酰胺 (区域精制法精制,熔段数:20);苄酰胺
英文名称
Benzamide
英文别名
Benzamide;BENZOIC ACID AMIDE;BENZOIC AMIDE;BENZOYLAMIDE;ai3-01031;amidkyselinybenzoove;amidkyselinybenzoove(czech);benzenecarboxamide;Carbonamide;phenylcarboxamide;Phenylcarboxyamide;BENZAMIDE CRYSTALLINE;BenzamideForSynthesis;Benzamide-ring-13C6;BENZOICACIDAMINOSALT;Benzamide Zone Refined (number of passes:20);Benzamid;BENZAMIDE pure;benzene amide;Benzene carbonaMide;benzoylamine;[
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Cas No.
55-21-0
分子式
C7H7NO
分子量
121.14
包装储存
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
生物活性
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity 体外研究. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature.
性状
Solid
IC50 & Target[1][2]
Human Endogenous Metabolite
体内研究(In Vivo)
Benzamide (160 mg/kg; IP, 2 injection by a 4 h interval) attenuates the METH-induced dopamine depletions.
Benzamide (160 mg/kg; IP, single dosage) has no acute effect on striatal dopamine metabolism and does not reduce body temperature.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
C57B1/6N mice (intraperitoneal injection of METH at 2-h intervals; 4 injections of 5 mg/kg, 4 injections of 10 mg/kg, or 2 injections of 20 mg/kg)
Dosage:
160 mg/kg
Administration:
IP, 2 injection by a 4 h interval
Result:
Partially and significantly attenuated the METH-induced dopamine depletions during the different METH treatment.
Animal Model:
C57B1/6N mice
Dosage:
160 mg/kg
Administration:
IP, single dosage
Result:
Had no acute effect on striatal dopamine metabolism and did not reduce body temperature.