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Acetylcysteine.

(Synonyms: 乙酰半胱氨酸; N-Acetylcysteine; N-Acetyl-L-cysteine; NAC)

目录号: PC14115 纯度: ≥98%

抗氧化剂;粘液溶解剂，Acetylcysteine是一种粘液溶解剂，可以减少粘液的厚度。

CAS No. :616-91-1

商品编号	规格	价格	会员价
PC14115-5g	5g	¥503.00	请登录
PC14115-10g	10g	¥630.00	请登录
PC14115-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥728.00	请登录

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中文名称	Acetylcysteine.
中文别名	N-乙酰半胱氨酸;N-乙酰-L-beta-巯基丙氨酸;N-乙酰-L-半胱氨酸;N-乙酰基-L-半胱氨酸;N-乙酰基-L-半胱氨酸辣;乙酰半胱氨酸;L-Α-乙酰氨基-Β-巯基丙酸;L-Α-乙酰胺基-Β-巯基丙酸;N-Acetyl-L-cysteine N-乙酰-L-半胱氨酸;N-L-乙酰半胱氨酸;N-乙酰-L-半胱氨酸(NAC);N-乙酰-L-半胱氨酸（乙酰半胱氨酸）;N-乙酰-L-半胱胺酸;N-乙酰-半胱氨酸;N-乙酰半胱氨酸标准品;N-乙酰半胱氨酸杂质对照品;N-乙酰半胱氨酸1;N-乙酰基-L-半胱氨酸(RG);乙酰半胱氨酸 EP标准品;乙酰半胱氨酸 USP标准品;乙酰半胱氨酸杂质A;N-乙酰-3-巯基丙氨酸;N-乙酰半胱氨酸,乙酰半胱氨酸;N-乙酰半胱氨酸,乙酰半胱氨酸,N-乙酰基-L-半胱氨酸;-乙酰-L-半胱氨酸;D-3-(2-萘基)-丙氨酸
英文名称	Acetylcysteine
英文别名	N-Acetylcysteine;(S)-ALPHA-AMINO-2-NAPHTHALENEPROPIONIC ACID;RARECHEM BK PT 0097;N-ACETYL-3-MERCAPTOALANINE;N-ACETYL-L-(+)-CYSTEINE;N-ACETYL-L-CYSTEINE;N-ALPHA-ACETYL-L-CYSTEINE;3-(2-NAPHTHYL)-ALANINE;(R)-2-Acetamido-3-mercaptopropanoic acid;Ac-Cys-OH;N-Acetyl-cysteine;(2R)-2-acetylamino-2-carboxyethanethiol;AC-ASP-GLU;AC-ASP-GLU H2O;AC-ASP-GLU-OH;Acetylcysteine;ACETYL-D-E;Acetyl-L-cysteine;Isospaglumic acid;LNAC;L-N-acetyl-cysteine;L-α-AcetaMido-β-Mercaptopropionic acid;NAAG;NAAGA;Naaxia;NAC;N-acetyl-(R)-cysteine;N-acetyl-aspartatylglutamate;N-acetylcycteine;N-acetyl-L-aspartyl-L-glutamate;N-acetyl-L-aspartyl-L-glutamic acid;SPAGLUMIC ACID;N-乙酰-L-半胱氨酸;mercapturic acid;Acetadote;L-Acetylcysteine;Broncholysin;Mucomyst;Fluimucil;Fluprowit;Parvolex;Fabrol;Airbron;Acetein;Fluimucetin;Acetylcysteinum;Acetilcisteina;Mucosolvin;Flumucetin;Mucosil;Brunac;Fluimicil Infantil;Lysomucil;Mucofilin;Respaire;Inspir;Exomuc;Mucolytikum Lappe;Mucolyticum Lappe;N-Acetyl cysteine;Mucolyticum;Neo-fluimucil;NAC-TB;Muco
Cas No.	616-91-1
分子式	C₅H₉NO₃S
分子量	163.19
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

生物活性

Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities.

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

体外研究(In Vitro)

Acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. Acetylcysteine also prevents death of PC12 cells and sympathetic neurons.
Acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells.
Acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. Acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. Acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. Acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it is suggested that Acetylcysteine interferes with redox-sensitive steps in the NGF mechanism.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Acetylcysteine (150, 300 mg/kg) treatment significantly reduces liver transaminases in all groups of treatment, mostly in group Acetylcysteine 300. Lung glutathione peroxidase is significantly increases in group Acetylcysteine 300 (P=0.04), while the other oxidation biomarkers show no significant differences.
Acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, protect from light
In solvent : -80°C, 6 months;
-20°C, 1 month (protect from light)

ClinicalTrial

结构分类

Ketones, Aldehydes, Acids

参考文献

[1]. Halasi M, et al. ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors. Biochem J. 2013 Sep 1;454(2):201-8.

[2]. Ferrari G, et al. N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci. 1995 Apr;15(4):2857-66.

[3]. Tsai JC, et al. Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem. 1996 Feb 16;271(7):3667-70.

[4]. Yan CY, et al. Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. J Neurosci. 1998 Jun 1;18(11):4042-9.

[5]. Farr SA, et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem. 2003 Mar;84(5):1173-83.

[6]. Kalimeris K, et al. N-acetylcysteine ameliorates liver injury in a rat model of intestinal ischemia reperfusion. J Surg Res. 2016 Dec;206(2):263-272.

[7]. Garigliany MM, et al. N-acetylcysteine lacks universal inhibitory activity against influenza A viruses. J Negat Results Biomed. 2011 May 9;10:5.

溶解度数据

体外研究:

H₂O : 163 mg/mL (998.84 mM; ultrasonic and adjust pH to 7 with NaOH)

DMSO : ≥ 100 mg/mL (612.78 mM)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.1278 mL	30.6391 mL	61.2783 mL
5 mM	1.2256 mL	6.1278 mL	12.2557 mL
10 mM	0.6128 mL	3.0639 mL	6.1278 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 120 mg/mL (735.34 mM); Clear solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Acetylcysteine.

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