8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity.
性状
Solid
IC50 & Target[1][2]
pKi: 8.23 (Melatonin MT2 receptor) and 8.95 (Melatonin MT1 receptor)
体内研究(In Vivo)
8-M-PDOT (10 μg/μL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Male Wistar rats (280-320 g) with Rotenone
Dosage:
10 μg/μL
Administration:
Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes
Result:
Increased percentage of time spent in the open arms and in the number of open arms entries.