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CD 2665

目录号: PC15243 纯度: ≥98%

RARβ/γ选择性拮抗剂，CD2665 是一种选择性的 RAR-beta/gamma 拮抗剂，对 RARγ 和 RARβ 作用的 Ki 值分别为 110 nM、306 nM。

CAS No. :170355-78-9

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中文名称

CD 2665

英文名称

CD 2665

英文别名

Benzoic acid,4-[6-[(2-methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl]-;4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic acid;CD 2665;4-[7-(1-ADAMANTYL)-6-(2-METHOXYETHOXYMETHOXY)NAPHTHALEN-3-YL]BENZOIC ACID;4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid;4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoicacid;CD2665;GTPL2654;VGA35578;4-(6-((2-Methoxyethoxy)methoxy)-7-tricyclo(3.3.1.1.3,7)dec-1-yl-2-naphthalenyl)Benzoic acid;B7501;Q27075801;4-[7-(1-adamantyl)-6-methoxyethoxymethoxy-2-naphthyl]benzoic acid;Benzo

Cas No.

170355-78-9

分子式

C₃₁H₃₄O₅

分子量

486.60

包装储存

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

详情描述

RARβ/γ选择性拮抗剂，CD2665 是一种选择性的 RAR-beta/gamma 拮抗剂，对 RARγ 和 RARβ 作用的 Ki 值分别为 110 nM、306 nM。

生物活性

CD2665 is an orally active and selective RAR-β,γ antagonist, with K_d values of 306 nM, 110 nM for RAR-β and RAR-γ, repectively.

性状

Solid

IC50 & Target[1][2]

Ki: 110 nM (RARγ), 306 nM (RARβ)

体外研究(In Vitro)

CD2665 (100 nM; 9 days; 3T3 cells) has significant effects on cell growth and differentiation.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	3T3 cells
Concentration:	100 nM
Incubation Time:	9 days
Result:	Abrogated the antiprolferative effects of ATRA , CD271 (adapalene, an RAR-β,γ agonist), and CD2043 (RAR-α,β,γ pan-agonist) returning cell numbers and percent LFCS to control level.

体内研究(In Vivo)

CD2665 (0.6 mg/kg; Subcutaneous injection; daily, for 22 days) completely inhibits the overexpression of RARβ mRNA in the brain of alcohol treated mice.
CD2665 is a selective retinoid antagonist and elicits the expected maturation delay and growth plate expansion.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice submitted to 10 months of ethanol consumption.
Dosage:	0.6 mg/kg
Administration:	Subcutaneous injection; daily, for 22 days.
Result:	Decreased brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels.

Animal Model:	Male and female mice (3 weeks).
Dosage:	1.6 mg/kg
Administration:	Oral gavage/intragastric; daily, for 31 days.
Result:	Growth plate closure had largely been prevented in LDE225/antagonist co-treated mice compared with those receiving LDE225 only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. Kim MJ, et al. The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J Invest Dermatol. 2000 Feb;114(2):349-53. [Information]

[2]. Alfos S, Boucheron C, et al. A retinoic acid receptor antagonist suppresses brain retinoic acid receptor overexpression and reverses a working memory deficit induced by chronic ethanol consumption in mice. Alcohol Clin Exp Res. 2001 Oct;25(10):1506-14. [Information]

[3]. Koyama E, et al.Premature Growth Plate Closure Caused by a Hedgehog Cancer Drug Is Preventable by Co-Administration of a Retinoid Antagonist in Mice. J Bone Miner Res. 2021 Jul;36(7):1387-1402. [Information]

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Data Sheet

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

CD 2665

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