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CNQX

AMPA/红藻氨酸受体拮抗剂,CNQX (FG9065) 是高效的 AMPA/kainate 受体拮抗剂。

目录号: PC12080 纯度: ≥98%

CAS No. :115066-14-3

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中文名称

CNQX

中文别名

6 -氰基- 7 -硝基喹喔啉-2,3二酮;6-氰基-7-硝基喹喔啉-2,3-二酮;1,2,3,4-四氢-7-硝基-2,3-二氧-6-喹啉甲腈;2-(4-氯苯基)-2-甲基吗啉;1,2,3,4-四氢-7-硝基-2,3-二氧代-6-喹喔啉甲腈;4-四氢-7-硝基-2;3-二氧代-6-喹喔啉甲腈

英文名称

CNQX

英文别名

6-Quinoxalinecarbonitrile,1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-;CNQX;6-CYANO-7-NITROQUINOXALINE- 2,3-DIONE;CNQX Disodium;6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate;6-Cyano-7-nitroquinoxaline-2,3-dione FG-9065;6-Nitro-7-cyanoquinoxaline-2,3-dione;AMPA RECEPTOR;CNOX;CNQX 2NA;CNQX DISODIUM KAINATE;CNQX DISODIUM SALT;CNQX disodium salt hydrate;FG-9065;2,3-Dioxo-7-nitro-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile;6-Cyano-2,3-dihydroxy-7-nitroquinoxaline;FG 9065;CNQX (FG-9065) (6-CYANO-7-NITROQUINO;6-Cyano-7-nitroquinoxaline-2,3-dione;CNQX DISODIUM KAINATE/AMPA RECEPTOR;7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile;6OTE87SCCW;7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile;1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile;6-Quinoxalinecarbonitrile, 1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-;ST50405216;2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile;FG9065;[3H]CNQX;Lo

Cas No.

115066-14-3

分子式

C₉H₄N₄O₄

分子量

232.15

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats.

性状

Solid

IC50 & Target[1][2]

IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)

体外研究(In Vitro)

CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 180-200 g
Dosage:	0.75, 1.5, and 3 mg/kg
Administration:	IP; 20 min before testing
Result:	Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. T Honoré, et al. Quinoxalinediones: Potent Competitive non-NMDA Glutamate Receptor Antagonists. Science. 1988 Aug 5;241(4866):701-3. [Information]

[2]. Neuman RS, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione(CNQX) in the hippocampus 体外研究. Neurosci Lett. 1988 Sep 23;92(1):64-8. [Information]

[3]. Alford S, et al. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 1990 Jan 8;506(2):297-302. [Information]

[4]. Pia B?ckstr?m, et al. Attenuation of Cocaine-Seeking Behaviour by the AMPA/kainate Receptor Antagonist CNQX in Rats. Psychopharmacology (Berl). 2003 Feb;166(1):69-76. [Information]

[5]. Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59(1):5-8. [Information]

溶解度数据

体外研究:

DMSO : 20 mg/mL (86.15 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.3076 mL	21.5378 mL	43.0756 mL
5 mM	0.8615 mL	4.3076 mL	8.6151 mL
10 mM	0.4308 mL	2.1538 mL	4.3076 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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