Lipid 5|2089251-33-0|-陌孚医药/Medlife

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Lipid 5

目录号: PL13108

CAS No. :2089251-33-0

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中文名称	Lipid 5
英文名称	Lipid 5
英文别名	Lipid 5;OCCN(CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC)CCCCCCCC(=O)OCCCCCCCCC;Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate
Cas No.	2089251-33-0
分子式	C₄₄H₈₇NO₅
分子量	710.17
包装储存	Pure form -20°C 3 years；4°C 2 years

产品详情	Lipid 5 是一种氨基脂质，可在啮齿动物和灵长类动物模型中提供有效的 mRNA 递送。Lipid 5 显示出最佳的药代动力学和无毒副作用。
生物活性	Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.
性状	Liquid
体外研究(In Vitro)	Replacement of the linoleic tail with a primary ester-containing lipid tail (Lipid 5) provids increased expression and optimal tissue clearance. The metabolite identification studies with Lipid 5 indicated that hydrolysis of the primary ester is the first step in the metabolism of the lipid. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Pure form -20°C 3 years；4°C 2 years
参考文献	[1]. Staci Sabnis, et al. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates. Mol Ther. 2018 Jun 6;26(6):1509-1519.

溶解度数据	In Vitro: DMSO : 100 mg/mL (140.81 mM; Need ultrasonic)配制储备液

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