Fluorescein Diacetate|596-09-8|(荧光素二乙酸酯; 3,6-Diacetoxyfluoran; Di-O-acetylfluorescein)-陌孚医药/Medlife

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Fluorescein Diacetate (Synonyms: 荧光素二乙酸酯; 3,6-Diacetoxyfluoran; Di-O-acetylfluorescein)

目录号: PL13117 纯度: ≥99%

CAS No. :596-09-8

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中文名称	Fluorescein Diacetate
中文别名	荧光素二乙酸盐;二乙酸荧光素;荧光素二乙酸酯;DL-樟脑酸;Fluorescein Diacetate 荧光素二乙酸酯;Fluorescein diacetate 二乙酸荧光素;二乙酸荧光素 USP标准品;二乙酸荧光素(FDA);二乙酸荧光素(FDA),BR;二乙酸萤光素;二乙酰荧光素;二乙酰荧光素 EP标准品;荧光素双醋酸酯;FDA,荧光素二乙酸酯;二乙酸荧光素酯;荧光胺双乙酸盐
英文名称	Fluorescein Diacetate
英文别名	Fluorescein diacetate;Diacetylfluorescein;Fluorescein Diacetat;(6'-acetyloxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate;3,6-Diacetoxyfluoran;Cellstain FDA;Di-O-acetylfluorescein;3-Oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl diacetate;FDA;3',6'-Diacetylfluorescein;Fluorescein, diacetate;MLS000722997;YL39R93PRE;Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-bis(acetyloxy)-;SMR000236387;NSC4726;CHADEQDQBURGHL-UHFFFAOYSA-N;3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate;C24H16O7;NSC667259;Fluo;Fluorescein Diacetate
Cas No.	596-09-8
分子式	C₂₄H₁₆O₇
分子量	416.38
包装储存	-20°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	Fluorescein diacetate 是一种细胞渗透性的酯酶底物。Fluorescein diacetate 可作为人谷胱甘肽硫转移酶 Pi (hGSTP1-1) 的荧光底物。
生物活性	Fluorescein diacetate is a cell permeable esterase-substrate. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1.
性状	Solid
体外研究(In Vitro)	Fluorescein diacetate (FDA) is an acetylated derivative of the green fluorescent dye fluorescein. Fluorescein diacetate (FDA), a fluorescent probe used for vital staining, is a fluorescently activated by esterolytic activity of human Pi-class glutathione S-transferase (hGSTP1) selectively among various cytosolic GSTs. Fluorescence activation of Fluorescein diacetate susceptible to GST inhibitors is observed in MCF7 cells exogenously overexpressing hGSTP1, but not in cells overexpressing hGSTA1 or hGSTM1. Fluorescein diacetate can be used as a fluorogenic substrate for hGSTP1-1. To investigate whether the fluorescence activation is due to hGSTP1 activity, Fluorescein diacetate is incubated with recombinant hGSTP1-1 and GSH in vitro. Remarkable fluorescence activation is observed in the presence of both hGSTP1-1 and GSH, whereas only slight activation is observed in the absence
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Boyd V, et al. Limitations in the Use of Fluorescein Diacetate/Propidium Iodide (FDA/PI) and Cell PermeableNucleic Acid Stains for Viability Measurements of Isolated Islets of Langerhans. Curr Trends Biotechnol Pharm. 2008 Mar;2(2):66-84. [2]. Fujikawa Y, et al. Fluorescein diacetate (FDA) and its analogue as substrates for Pi-class glutathione S-transferase (GSTP1) and their biological application. Talanta. 2018 Mar 1;179:845-852.

溶解度数据	In Vitro: DMSO : 26.67 mg/mL (64.05 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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