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Garenoxacin Mesylate hydrate

(Synonyms: 加雷沙星甲磺酸盐; BMS284756 Mesylate hydrate)

目录号: PL12393 纯度: ≥99%

Garenoxacin (BMS284756) Mesylate hydrate 是一种具有口服活性的喹诺酮类抗生素 (antibiotic)，对各种革兰氏阳性和革兰氏阴性细菌、厌氧菌和复养微生物具有广泛的活性。

CAS No. :223652-90-2

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中文名称	Garenoxacin Mesylate hydrate
中文别名	甲磺酸加雷沙星一水合物;1-环丙基-8-(二氟甲氧基)-7-[(1R)-2,3-二氢-1-甲基-1H-异吲哚-5-基]-1,4-二氢-4-氧代-3-喹啉甲酸甲磺酸盐一水合物;甲磺酸加雷沙星;甲磺酸加雷沙星杂质对照品;加雷沙星甲磺酸盐
英文名称	Garenoxacin Mesylate hydrate
英文别名	Garenoxacin mesylate hydrate;1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate;1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid,methanesulfonic acid,hydrate;Garenoxacin (Mesylate hydrate);GARENOXACIN MESYLATE;1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-5-isoindolyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate monohydrate;Garenoxacin mesilate;Geninax;Inforce;1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methane sulfonic acid salt monohydrate;BMS 284756 mesylate;Ganefloxacin mesylate;Garenfloxacin mesylate;T-3811 mesylate;Garenoxacin;BMS284756 Mesylate hydrate;Garenoxacin Mesylate hydrate
Cas No.	223652-90-2
分子式	C₂₃H₂₀N₂O₄F₂^.CH₄O₃S^.H₂O
分子量	540.53
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Garenoxacin (BMS284756) Mesylate hydrate 是一种具有口服活性的喹诺酮类抗生素 (antibiotic)，对各种革兰氏阳性和革兰氏阴性细菌、厌氧菌和复养微生物具有广泛的活性。

产品详情	Garenoxacin (BMS284756) Mesylate hydrate 是一种具有口服活性的喹诺酮类抗生素 (antibiotic)，对各种革兰氏阳性和革兰氏阴性细菌、厌氧菌和复养微生物具有广泛的活性。
生物活性	Garenoxacin (BMS284756) Mesylate hydrate is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms.
性状	Solid
IC50 & Target[1][2]	Quinolone Gyrase 1.25 μg/mL (IC50)
体外研究(In Vitro)	Garenoxacin (BMS284756) (0-8 days) inhibits mycoplasmas and ureaplasmas with MIC90s ≤0.25 μg/mL against tested strains. Garenoxacin (48 h) inhibits S. aureus wild type and mutants with MICs of 0.0128-4.0 μg/mL. Garenoxacin inhibits topoisomerase IV and gyrase from S. aureus with IC50s of 1.25 to 2.5 and 1.25 μg/mL, respectively. Garenoxacin has a low propensity for selective enrichment of fluoroquinolone-resistant mutants among ciprofloxacin-susceptible isolates of S. aureus . has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Garenoxacin (12.5-50 mg/kg; s.c.; once) is highly effective against the wild-type strain and mutants harboring a single mutation in a mouse pneumonia model with S. pneumonia infection. Garenoxacin (10 and 30 mg/kg; p.o.; once) reduces the viable cell counts in the lungs and significantly prolongs survival on experimental secondary pneumococcal pneumonia caused by S. pneumoniae D-979 in BALB/c female mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Waites KB, et al. In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrob Agents Chemother. 2003 Jan;47(1):161-5. [2]. Ince D, et al. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother. 2002 Nov;46(11):3370-80.

溶解度数据	In Vitro: DMSO : 100 mg/mL (185.00 mM; Need ultrasonic)H₂O : 12.5 mg/mL (23.13 mM; Need ultrasonic)配制储备液

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[1]. Waites KB, et al. In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrob Agents Chemother. 2003 Jan;47(1):161-5.
[2]. Ince D, et al. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother. 2002 Nov;46(11):3370-80.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Garenoxacin Mesylate hydrate

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