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产品总数：60959
| 中文名称 |
L-Thyroxine sodium
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|---|---|
| 中文别名 |
左甲状腺素钠;左旋甲状腺素钠;甲碘四安钠盐;甲状腺素;L-甲状腺素钠盐五水合物;L-Thyroxine Sodium Salt Pentahydrate L-甲状腺素钠盐五水合物;L-甲状腺素钠;左甲状腺素钠粉;左旋甲状腺素钠 水合物;L-甲状腺素钠五水合物;small>-甲状腺素钠盐五水合物;(S)-2-氨基-3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]丙酸钠盐 五水合物;湖北扬信现货供应左甲状腺素钠杂质ABCDE
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| 英文名称 |
L-Thyroxine sodium
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| 英文别名 |
L-Thyroxine sodium;Thyroxinesodiumsalt;L-Thyroxine sodium salt;sodium 4-o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosine;Sodium Levothyroxine;Levothyroxine sodium;Levothyroxine sodium hydrate;Thyroxine;(S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid Sodium Salt Pentahydrate;L<;Sodium (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionate Pentahydrate;12,18,30,36,50,56-Hexamethyl-22,40,60-tris(4-methylphenyl)-5-sulfanylidene-8,22,26,40,46,60-hexaza-5;12,18,30,36,50,56-Hexamethyl-22,40,60-tris(4-methylphenyl)-8,22,26,40,46,60-hexaza-5lambda5-phosphao;Berlthyrox;L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1);Levothyroxine Sodium [USAN:INN];Levoxyl;Thyroxine sodique;Thyroxin sodium;Tirosint-Sol;Sodium L-thyroxine;Levothyroxine sodique;D-3,5-Diiodo-4-(3',5'-Diiodo-4'-hydroxyphenoxy)-phenylalanine sodium salt;LEVOTHYROXINE SODIUM [WHO-DD];Thyradin;MFCD00002596;Tiroidina;EINECS 200-221-4;sodium;(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate;CS-O-02455;Thyroxinique;Eferox;Levothyroxine sodium tablets;LS-153817;UNII-054I36CPMN;Levothyroxine Sodium [USAN];Q27107208;Tyrosint;Synthroid sodium;054I36CPMN;Letter;L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodiumsalt;3,3',5,5'-Tetraiodo-L-thyronine, sodium salt;Levothyroxine sodium anhydrous;LT4 sodiumL-T4 sodium;AKOS024284731;Levothyroxinum natricum [INN-Latin];NSC 259940;Thyroxine sodium salt;AC-10210;Levothyroxinum natricum;CCG-270489;Levothyroxine sodium;T4 sodium;Unithroid;L-T4 Sodium;Sodium l-thyroxin;SCHEMBL34102;L-THYROXINESODIUMSALT,HYDRATE;Thyronamin;Thyrax Sodium;25416-65-3;sodium (S)-2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate;C15H11I4NO4.Na;Levaxin;AS-83570;Levothyroxine for peak identification;LEVOTHYROXINE SODIUM ANHYDROUS [WHO-IP];C08212;Sodium levothyroxine;THYROID;L-Tirosina, O-(4-hidroxi-3,5-diiodofenil)-3,5-diiodo-, sal de sodio (1:1);Tirosint;Levothyroxine sodique [INN-French];Levotiroxina sodica [INN-Spanish];Levothyroxine Sodium (anhydrous);Oroxine;CS-0031276;Sodium (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionate;Laevoxin;AC-919;Thyroxinum natricum;AMY14441;C15-H11-I4-N-O4.Na;Levothyroxine sodium (INN);(S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid Sodium Salt;AKOS015918420;Levotiroxina sodica;HY-18341B;Roxstan;D11113;55-03-8;eltroxin;Levoroxine;Thyroxevan;NSC-259940;Levothyroxin-natrium;levothyroxinnatrium-;Tetroid;Leventa;synthroid;Sodium thyroxinate;Euthyrox;LEVOTHYROXINE SODIUM [INN];L-Thyroxine (sodium);LS-153822;LT4 sodium;sodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate;Thyroxine Soduim Salt;DTXSID90883228;Soloxine;Dathroid;levotiroxina de sodio;Thyroxine, monosodium salt, L-;Epitope ID:136776;L-Thyroxine sodium xh...
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| Cas No. |
55-03-8
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| 分子式 |
C87H63N6OP
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| 分子量 |
1239.44
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| 包装储存 |
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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| 产品详情 |
L-Thyroxine sodium (Levothyroxine sodium) 是一种合成的甲状腺激素，用于甲状腺功能减退症的研究。DIO 酶将 L-Thyroxine (T4) 转化成具有生物活性的三碘甲状腺氨酸 (T3)。
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| 生物活性 |
L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
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| 性状 |
Solid
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| IC50 & Target[1][2] |
Human Endogenous Metabolite
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| 体内研究(In Vivo) |
Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronin
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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| ClinicalTrial |
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| 参考文献 |
[1]. Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.[2]. Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.
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| 溶解度数据 |
In Vitro: DMSO : 62.5 mg/mL (78.24 mM; Need ultrasonic)0.5 M NaOH : 25 mg/mL (31.29 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 60°C)H2O : 14 mg/mL (17.53 mM; ultrasonic and adjust pH to 12 with NaOH)
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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