Cecropin P1, porcine is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine shows antiviral activity and inhibits PRRSV infection.
性状
Solid
体外研究(In Vitro)
Cecropin P1, porcine (0-480 μg/mL, 36-96 h) markedly inhibits CH-1a infection and replication in Marc-145 cells.Cecropin P1, porcine (0-480 μg/mL, 36 h) not only displays extracellular virucidal activity against PRRSV (porcine reproductive and respiratory syndrome virus), but also exerts a potent inhibitory effect when added either before, simultaneously with, or after viral inoculation. Cecropin P1, porcine (480 μg/mL, 0-72 h) blocks CH-1a-induced apoptosis during the late phase of infection.Cecropin P1, porcine (0-480 μg/mL, 0-4 h) inhibits viral particle release. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Cecropin P1 (1 mg/kg, IP, once) prevents bacterial growth, endotoxemia, and mortality in rats with septic shock. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
[1]. Andersson M, et al. Ascaris nematodes from pig and human make three antibacterial peptides: isolation of cecropin P1 and two ASABF peptides. Cell Mol Life Sci. 2003 Mar;60(3):599-606. [2]. Guo C, et al. Cecropin P1 inhibits porcine reproductive and respiratory syndrome virus by blocking attachment. BMC Microbiol. 2014 Nov 18;14:273.
溶解度数据
In Vitro: H2O : 50 mg/mL (14.98 mM; Need ultrasonic)配制储备液
[1]. Andersson M, et al. Ascaris nematodes from pig and human make three antibacterial peptides: isolation of cecropin P1 and two ASABF peptides. Cell Mol Life Sci. 2003 Mar;60(3):599-606. [2]. Guo C, et al. Cecropin P1 inhibits porcine reproductive and respiratory syndrome virus by blocking attachment. BMC Microbiol. 2014 Nov 18;14:273.