Cecropin P1, porcine

目录号: PL12041 纯度: ≥99%
Cecropin P1, porcine 是一种抗菌 (antibacterial) 肽,可从猪小肠上部分离。Cecropin P1, porcine 对革兰氏阴性菌具有抗菌活性。Cecropin P1, porcine 具有抗病毒 (antiviral) 活性,可抑制 PRRSV 感染。
CAS No. :125667-96-1
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中文名称
Cecropin P1, porcine
中文别名
蛔虫抗菌肽P1
英文名称
Cecropin P1, porcine
英文别名
L-Arginine, L-seryl-L-tryptophyl-L-leucyl-L-seryl-L-lysyl-L-threonyl-L-alanyl-L-lysyl-L-lysyl-L-leucyl-L-a-glutamyl-L-asparaginyl-L-seryl-L-alanyl-L-lysyl-L-lysyl-L-arginyl-L-isoleucyl-L-seryl-L-a-glutamylglycyl-L-isoleucyl-L-alanyl-L-isoleucyl-L-alanyl-L-isoleucyl-L-glutaminylglycylglycyl-L-prolyl-;Cecropin P1;Cecropin P1 (porcine);L-Arginine, L-seryl-L-tryptophyl-L-leucyl-L-seryl-L-lysyl-L-threonyl-L-alanyl-L-lysyl-L-lysyl-...;L-Arginine, L-seryl-L-tryptophyl-L-leucyl-L-seryl-L-lysyl-L-threonyl-L-alanyl-L-lysyl-L-lysyl-L-leucyl-L-a-glutamyl-L-asparag;L-Arginine, L-seryl-L-tryptophyl-L-leucyl-L-seryl-L-lysyl-L-threonyl-L-alanyl-L-lysyl-L-lysyl-L-leucyl-L-a-glutamyl-L-asparaginyl-L-seryl-L-alanyl-L-lysyl-L-lysyl-L-arginyl-L-isoleucyl-L-seryl-L-a-glu;SER-TRP-LEU-SER-LYS-THR-ALA-LYS-LYS-LEU-GLU-ASN-SER-ALA-LYS-LYS-ARG-ILE-SER-GLU-GLY-ILE-ALA-ILE-ALA-ILE-GLN-GLY-GLY-PRO-ARG;cecropin P1-LI;Porcine cecropin;Aids096086;Aids-096086;H-SER-TRP-LEU-SER-LYS-THR-ALA-LYS-LYS-LEU-GLU-ASN-SER-ALA-LYS-LYS-ARG-ILE-SER-GLU-GLY-ILE-ALA-ILE-ALA-ILE-GLN-GLY-GLY-PRO-ARG-OH;Cecropin P1 Porcine;NV7O3PE13N;cecropin P1;CECROPIN P1 (PORCINE)
Cas No.
125667-96-1
分子式
C147H253N45O43
分子量
3338.86
包装储存
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
详情描述
Cecropin P1, porcine 是一种抗菌 (antibacterial) 肽,可从猪小肠上部分离。Cecropin P1, porcine 对革兰氏阴性菌具有抗菌活性。Cecropin P1, porcine 具有抗病毒 (antiviral) 活性,可抑制 PRRSV 感染。
产品详情
Cecropin P1, porcine 是一种抗菌 (antibacterial) 肽,可从猪小肠上部分离。Cecropin P1, porcine 对革兰氏阴性菌具有抗菌活性。Cecropin P1, porcine 具有抗病毒 (antiviral) 活性,可抑制 PRRSV 感染。
生物活性
Cecropin P1, porcine is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine shows antiviral activity and inhibits PRRSV infection.
性状
Solid
体外研究(In Vitro)
Cecropin P1, porcine (0-480 μg/mL, 36-96 h) markedly inhibits CH-1a infection and replication in Marc-145 cells.
Cecropin P1, porcine (0-480 μg/mL, 36 h) not only displays extracellular virucidal activity against PRRSV (porcine reproductive and respiratory syndrome virus), but also exerts a potent inhibitory effect when added either before, simultaneously with, or after viral inoculation.
Cecropin P1, porcine (480 μg/mL, 0-72 h) blocks CH-1a-induced apoptosis during the late phase of infection.
Cecropin P1, porcine (0-480 μg/mL, 0-4 h) inhibits viral particle release. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Cecropin P1 (1 mg/kg, IP, once) prevents bacterial growth, endotoxemia, and mortality in rats with septic shock. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
SequenceShortening
SWLSKTAKKLENSAKKRISEGIAIAIQGGPR
Sequence
Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile-Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg
参考文献
[1]. Andersson M, et al. Ascaris nematodes from pig and human make three antibacterial peptides: isolation of cecropin P1 and two ASABF peptides. Cell Mol Life Sci. 2003 Mar;60(3):599-606.
[2]. Guo C, et al. Cecropin P1 inhibits porcine reproductive and respiratory syndrome virus by blocking attachment. BMC Microbiol. 2014 Nov 18;14:273.
溶解度数据
In Vitro: H2O : 50 mg/mL (14.98 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)
[1]. Andersson M, et al. Ascaris nematodes from pig and human make three antibacterial peptides: isolation of cecropin P1 and two ASABF peptides. Cell Mol Life Sci. 2003 Mar;60(3):599-606.
[2]. Guo C, et al. Cecropin P1 inhibits porcine reproductive and respiratory syndrome virus by blocking attachment. BMC Microbiol. 2014 Nov 18;14:273.

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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