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| 中文名称 |
Piroctone olamine
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|---|---|
| 中文别名 |
羟吡酮;吡啶酮乙醇胺盐;吡罗克酮乙醇胺盐;Piroctone Olamine 吡罗克酮乙醇胺盐;吡啶酮氨基乙醇胺盐;吡啶酮氨基乙醇盐;吡罗克酮乙醇铵 USP标准品;吡罗克酮乙醇胺;1-羟基-4-甲基-6-(2,4,4-三甲苯基)吡啶酮乙醇胺复合盐;1-羟基-4-甲基-6-(2,4,4-三甲苯基)吡啶酮乙醇胺复合盐(1:1);1-羟基-4-甲基-6-(2,4,4-三甲基戊基)-2(1H)-吡啶酮乙醇胺;吡啶酮乙醇胺盐(去屑剂OCTO);吡罗克酮乙醇铵;去屑剂;1-羟基-4-甲基-6-(2,4,4-三甲基戊基)-2(1H)-吡啶酮 乙醇胺盐;优质高纯度，吡啶酮乙醇胺盐
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| 英文名称 |
Piroctone olamine
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| 英文别名 |
PIROCTONE OLEAMINE;piroctone olamine;1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt;OCTO;Piroctone ethanolamine;Piroctone olamine;1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine;Octopirox;Kopirox;Piroctone olamine [USAN];C14H23NO2.C2H7NO;1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1);Piroctone olamine (USAN);2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1);1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1);2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimeth;Piroctone;1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt;Piroctone olamine
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| Cas No. |
68890-66-4
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| 分子式 |
C16H30N2O3
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| 分子量 |
298.42
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| 包装储存 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| 产品详情 |
Piroctone olamine 是一种吡啶衍生物。具有杀真菌作用。
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| 生物活性 |
Piroctone olamine is a pyridine derivate. It is known to have a fungicidal effect.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
Antifungal
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| 体外研究(In Vitro) |
Piroctone olamine, the ethanolamine salt of the hydroxamic acid derivative Piroctone, is a hydroxypyridone anti-mycotic agent. Piroctone olamine penetrates the cell membrane and forms complexes with iron ions, inhibiting energy metabolism in mitochondria. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL). has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
This work aimed to evaluate the antifungal activity of Piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The treatment with Piroctone olamine (0.5 mg/kg) is performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n=6) is treated with Amphotericin B (0.5 mg/kg). The mycological diagnosis is made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality are analyzed statistically by Student’s t test and analysis of variance, with level of significance set at P<0.05. The difference in fungal growth scoring between the control group and the treatment groups (Piroctone olamine and Amphotericin B) is statistically significant (P<0.05). has not independently confirmed the accuracy of
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| 参考文献 |
[1]. Youn HJ, et al. Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study. Ann Dermatol. 2016 Dec;28(6):733-739.[2]. do Couto FM, et al. Antifungal activity of the piroctone olamine in experimental intra-abdominal candidiasis. Springerplus. 2016 Apr 16;5:468.
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| 溶解度数据 |
In Vitro: H2O : 50 mg/mL (167.55 mM; ultrasonic and adjust pH to 9 with NaOH)DMSO : 11.11 mg/mL (37.23 mM; Need ultrasonic)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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