T-2307|873546-31-7|-陌孚医药/Medlife

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T-2307

目录号: PL12172 纯度: ≥99%

CAS No. :873546-31-7

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中文名称	T-2307
英文名称	T-2307
英文别名	4-[3-[1-[3-(4-carbamimidoylphenoxy)propyl]piperidin-4-yl]propoxy]benzenecarboximidamide;GMD55NSA1F;4-[3-[1-[3-(4-carbamimidoylphenoxy)propyl]piperidin-4-yl]propoxy]benzenecarboximidamide;T 2307 free base;4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine;4-{3-[4-{3-[4-[amino(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine;Benzenecarboximidamide, 4,4'-(1,4-piperidinediylbis(3,1-propanediyloxy))bis;Q27279175;4-[3-[1-[3-(4-carbamimidoylphenoxy;T-2307 free base;Echinocandin resistant;Echinocandin susceptible;All Candida albicans;T-2307
Cas No.	873546-31-7
分子式	C₂₅H₃₅N₅O₂
分子量	437.58
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	T-2307 是一种芳基脒，在体外和体内具有抗真菌活性。T-2307 具有广谱抗菌活性，包括念珠菌属 (Candida， MIC 为 0.00025 至 0.0078 μg/mL)、新型隐球菌属 (Cryptococcus neoformans，MIC 为 0.0039-0.0625 μg/mL) 和曲霉属 (Aspergillus；MIC 为 0.0156-4 μg/mL)。
生物活性	T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) .
性状	Solid
体外研究(In Vitro)	T-2307 exhibits potent activity against fluconazole-resistant and fluconazole-susceptible-dose-dependent Candida albicans strains as well as against azole-susceptible strains. T-2307 shows efficacy in a murine model of candida glabrata infection despite in vitro trailing growth phenomena. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	In mouse models of disseminated candidiasis, cryptococcosis, and aspergillosis, the ED 50 of T-2307 were 0.00755, 0.117, and 0.391 mg/kg, respectively. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Junichi Mitsuyama, et al. In vitro and in vivo antifungal activities of T-2307, a novel arylamidine. Antimicrob Agents Chemother. 2008 Apr;52(4):1318-24. [2]. Eio Yamada, et al. T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. Antimicrob Agents Chemother. 2010 Sep;54(9):3630-4.

溶解度数据	In Vitro: DMSO : 50 mg/mL (114.26 mM; ultrasonic and adjust pH to 3 with HCl)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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