Chitin synthase inhibitor 4 (compound 4fh) 是一种几丁质酶 (CHS) 抑制剂，具有杀菌效果。Chitin synthase inhibitor 4 是一种潜在的基于 CHS 的农业杀菌剂。

Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase (CHS) inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential CHS-based fungicide in agriculture.

Solid

Chitin synthase inhibitor 4 shows good antifungal activities against V. mali and S. sclerotiorum with EC50 values of 0.71 and 2.47 μg/mL, respectively.
Chitin synthase inhibitor 4 (50 μg/mL) displays potency inhibition against V. mali and S. sclerotiorum with inhibition rates of 90.3% and 88.7%, respectively.
Chitin synthase inhibitor 4 (1 μg/mL) blocks the hyphae growth, results abnormal growth, with inducing cell content decreasing, cell wall degradation, and plasmolysis.
Chitin synthase inhibitor 4 (50 μM; 3 h) exhibits inhibition against chitin synthase (CHS) and polyoxin D with inhibition rates of 68.08% and 63.84%, respectively.
has not independently confirmed the accuracy of these methods. They are for reference only.

Chitin synthase inhibitor 4 (50 μg/mL) has considerable curative and protective effects against S. sclerotiorum vivo, and no obvious phytotoxicity .
Chitin synthase inhibitor 4 has low acute toxicity, with no carcinogenic and mutagenic toxicity risk.
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Zhang X, et al. Synthesis, Antifungal Activity, and 3D-QASR of Novel 1,2,3,4-Tetrahydroquinoline Derivatives Containing a Pyrimidine Ether Scaffold as Chitin Synthase Inhibitors. J Agric Food Chem. 2022 Jul 21.