SN-011 是一种有效和选择性的 STING 抑制剂，抑制 STING 信号传导的 IC₅₀ 值为 76 nM。SN-011 与环状二核苷酸 (CDN) 竞争 STING 二聚体的结合口袋，从而阻断 CDN 结合和 STING 激活。SN-011 可用于 STING 驱动的自身免疫和炎症性疾病的研究。

SN-011 is a potent and selective mouse and human STING inhibitor, with an IC 50 of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease.

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IC50: 76 nM (STING signaling)

SN-011 (1 μM; pretreated for 6 h) significantly suppresses the STING stimulator-induced expression of Ifnb, Cxcl10, and Il6 mRNA in mouse embryonic fibroblasts (MEFs).
SN-011 (0.001-10 μM; pretreated for 6 h) inhibits 2′3′-cGAMP-induced Ifnb expression in MEFs, mouse bone marrow-derived macrophages (BMDMs) and human foreskin fibroblasts (HFFs) with IC50s of 127.5, 107.1, and 502.8 nM, respectively.
SN-011 (1 μM; pretreated for 3 h) inhibits 2′3′-cGAMP-induced STING oligomerization and phosphorylation in HFFs.
SN-011 (1 μM) suppresses HSV-1 infection (4 h), HT-DNA (1 h), or 2′3′-cGAMP stimulation (30 min) induced STING ER-to-Golgi translocation. has not independently confirmed the accuracy of these methods. They are for reference only.

SN-011 (5 mg/kg; i.p. 3 times weekly for a month) strongly inhibits hallmarks of inflammation and autoimmunity disease, and protects Trex1 mice from death. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Hong Z, et, al. STING inhibitors target the cyclic dinucleotide binding pocket. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2105465118.

In Vitro: DMSO : 100 mg/mL (216.22 mM; Need ultrasonic)配制储备液