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产品总数：61756
| 中文名称 |
Citric acid trisodium
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|---|---|
| 中文别名 |
柠檬酸三钠;柠檬酸钠,二水;柠檬酸三钠盐二水合物;二水柠檬酸钠;二水柠檬酸三钠;柠檬酸钠;柠檬酸钠(无水);柠檬酸 三钠盐;柠檬酸钠,无水;无水柠檬酸钠;枸椽酸钠;枸橼酸钠;柠檬酸三钠,AR;柠檬酸三钠,Cp;食品级柠檬酸钠;四合一磷化液;无水柠檬酸三钠;油性树脂色浆;2-羟基丙烷-1,2,3-三羧酸;柠檬酸三纳;柠檬酸盐浓缩液;食品级无水柠檬酸钠;68-04-2;枸橼酸钠、柠檬酸钠;柠檬酸三钠（无水)(分析标准品)
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| 英文名称 |
Citric acid trisodium
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| 英文别名 |
Sodium 2-hydroxypropane-1,2,3-tricarboxylate;anhydrous Sodium Citrate;trisodium 2-hydroxypropane-1,2,3-tricarboxylate anhydrous;Sodium citrate;trisodium citrate anhydrous;Trisodium citrate dihydrate;Citric acid trisodium salt;anhydrous trisodium citrate;citnatin;citreme;Citric acid;Citric acid 3Na;citrosodina;citrosodine;citrosodna;FEMA 3026;Na3-citrate;natrocitral;Sodium citrate, anhydrous;Trisodium citrate;2-Hydroxy-1,2,3-propanetricarboxylic acid trisodium salt;Sodium citrate anhydrous;Trisodium citrate, anhydrous;Citric acid, trisodium salt;1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt;FEMA No. 3026;Sodium citrate (Na3C6H5O7);RS7A450LGA
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| Cas No. |
68-04-2
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| 分子式 |
C6H5Na3O7
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| 分子量 |
258.07
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| 包装储存 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| 详情描述 |
Citric acid trisodium 是一种天然防腐剂和食品酸味增强剂。Citric acid trisodium 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期和 S 期。Citric acid trisodium 通过降低抗氧化酶活性引起肝脏的氧化损伤。Citric acid trisodium 对小鼠造成肾毒性。
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| 产品详情 |
Citric acid trisodium 是一种天然防腐剂和食品酸味增强剂。Citric acid trisodium 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期和 S 期。Citric acid trisodium 通过降低抗氧化酶活性引起肝脏的氧化损伤。Citric acid trisodium 对小鼠造成肾毒性。
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| 生物活性 |
Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
Human Endogenous Metabolite
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| 体外研究(In Vitro) |
Citric acid trisodium (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner.Citric acid trisodium (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.Citric acid trisodium (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver.
Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes.
Citric acid trisodium (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| ClinicalTrial |
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| 参考文献 |
[1]. Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82.[2]. Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44.[3]. Ying TH, et al. Citric acid induc
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| 溶解度数据 |
In Vitro: H2O : 100 mg/mL (387.49 mM; Need ultrasonic)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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