STING agonist-12|2259624-71-8|-陌孚医药/Medlife

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STING agonist-12

目录号: PL11508 纯度: ≥98%

CAS No. :2259624-71-8

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中文名称	STING agonist-12
英文名称	STING agonist-12
英文别名	1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-;STING activator Compound 53;1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide;STING agonist-12
Cas No.	2259624-71-8
分子式	C₂₅H₁₉ClF₄N₂O₂
分子量	490.88
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	STING agonist-12 (Compound 53) 是一种口服有效的人 STING 激活剂，EC₅₀ 为 185 nM。
生物活性	STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC 50 of 185 nM.
性状	Solid
IC50 & Target[1][2]	EC50: 185 nM (STING)
体外研究(In Vitro)	STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells. STING agonist-12 is not active at mouse STING. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Balb/c mice (n=3)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Pryde DC, et al. The discovery of potent small molecule activators of human STING. Eur J Med Chem. 2021 Jan 1;209:112869.

溶解度数据	In Vitro: DMSO : 250 mg/mL (509.29 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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