OD36 是一种 RIPK2 抑制剂，IC₅₀ 为 5.3 nM。OD36 是一种大环抑制剂，可与 ALK2 激酶 ATP 口袋有效结合。OD36 靶向作用于 ALK2，K_D 为 37 nM。

OD36 is a RIPK2 inhibitor with an IC 50 of 5.3 nM. OD36 is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 shows ALK2-directed activity with K D s of 37 nM.

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RIPK2 5.3 nM (IC50) ACVR1 37 nM (Kd)

OD36 also inhibits ALK2 and ALK2 R206H with IC50s of 47 and 22 nM, respevtively.
OD36 shows activity against ALK1 with a KD of 90 nM.
OD36 potently antagonize mutant ALK2 signaling and osteogenic differentiation.
OD36 (0.1-1 μM; 24 h) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5 in KS483 cells.
Preincubation of fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs) with OD36 (0.5 μM) completely prevents the activation of Smad1/5 and gene targets ID-1 and ID-3 in response to activin A. has not independently confirmed the accuracy of these methods. They are for reference only.

OD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice, muramyl dipeptide (MDP)-induced

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Justine T Tigno-Aranjuez, et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem. 2014 Oct 24;289(43):29651-64.
[2]. Gonzalo Sánchez-Duffhues, et al. Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells. JBMR Plus. 2019 Oct 7;3(11):e10230.

In Vitro: DMSO : 33.33 mg/mL (100.76 mM; ultrasonic and warming and heat to 60°C)配制储备液