PLpro inhibitor 是一种 papain-like protease (PLpro) 抑制剂，IC₅₀ 为 2.6 µM。PLpro inhibitor 还以 IC₅₀ 为 5.0 µM 和 EC₅₀ 为 21.0 µM 来抑制 SARS-CoV-2 PLpro。

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC 50 of 2.6 μM. PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC 50 of 5.0 μM and an EC 50 of 21.0 μM.

Solid

IC50 : 2.6 μM (Papain-like protease (PLpro)); 5.0 μM (SARS-CoV-2 PLpro)
EC50: 21.0 μM (SARS-CoV-2 PLpro)

PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1 μM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells. has not independently confirmed the accuracy of these methods. They are for reference only.

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Powder -20°C 3 years；4°C 2 years

[1]. Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24.
[2]. http://www.google.com/patents/WO2010022355A1cl=en
[3]. Brendan T Freitas, et al. Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SA

In Vitro: DMSO : 100 mg/mL (288.67 mM; Need ultrasonic)配制储备液