Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2.
体外研究(In Vitro)
Narsoplimab (100 nM; 3 h; Vero E6 细胞和带有 SARS-CoV-2 的 Vero E6 细胞) 抑制了 N 蛋白增强的 MASP-2 沉积。 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Narsoplimab (10 mg/kg; i.v.; WT and Masp2 (KO) mice) 降低了小鼠淋巴细胞百分比 (Lym%),增加了中性粒细胞百分比 (Neu%)。 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: WT and Masp2 (KO) mice (C57BL/6N, female,
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Gao T, et, al. Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation. Signal Transduct Target Ther. 2022 Sep 14;7(1):318.