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| 中文名称 |
Dalazatide TFA
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|---|---|
| 英文名称 |
Dalazatide TFA
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| 包装储存 |
Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
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| 产品详情 |
Dalazatide (ShK-186) TFA 是一种特异性的 Kv1.3 钾通道肽抑制剂。Dalazatide TFA 可用于自身免疫性疾病，如如多发性硬化症 (MS)、红斑狼疮、银屑病、类风湿性关节炎、1 型糖尿病和炎症性肠病的研究。
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| 生物活性 |
Dalazatide (ShK-186) TFA is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide TFA can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
Kv1.3
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| 体外研究(In Vitro) |
Dalazatide (ShK-186) (0-1000 pM) TFA 以剂量依赖的方式阻断卵巢特异性 GFP+ 效应记忆 T (Tem) 细胞中的 Kv1.3 电流，Kd 为 65 ± 5 pM。Dalazatide (0-100 nM; 3 days) TFA 以剂量依赖的方式抑制 CCR7 T 细胞增殖。Dalazatide (100 nM; 30 min) TFA 通过抑制钙信号通路固定炎症部位的效应记忆 T (Tem) 细胞，从而阻止 β1 整合素激活。 has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay-t
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| 体内研究(In Vivo) |
Dalazatide (ShK-186) (100 μg/kg; s.c.; once) TFA 在大鼠中抑制延迟型超敏反应，并抑制 Tem 细胞的体内运动和激活。 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: Lewis rats rats, delayed-type hypersensitivity (DTH)
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
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| Solvent&Solubility |
In Vitro:
H2O Peptide Solubility and Storage Guidelines:1. Calculate the length of the peptide.2. Calculate the overall charge of the entire peptide according to the following table: |
| 参考文献 |
[1]. Olsen C, et al. Dalazatide (ShK-186), a first-in-class peptide inhibitor of Kv1. 3 potassium channels, demonstrates safety, tolerability and proof of concept of efficacy in patients with active plaque psoriasis. J. Invest. Dermatol., 2016, 136(8).[2]. Stevens A M, et al. Thu0285 Dalazatide, an Inhibitor of the KV1. 3 Channel on Activated Effector Memory T Cells, Has Immunotherapy Potential in Systemic Lupus Erythematosus. 2016.
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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