Pioglitazone|111025-46-8|(吡格列酮; U 72107)-陌孚医药/Medlife

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Pioglitazone (Synonyms: 吡格列酮; U 72107)

目录号: PL10068 纯度: ≥99%

CAS No. :111025-46-8

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中文名称	Pioglitazone
中文别名	匹格列酮;盐酸吡格列酮;5-[[4-[2-(5-乙基吡啶-2-基)乙氧基]苯基]甲基]-1,3-噻唑烷-2,4-二酮;5-[4-[2-(5-乙基-2-吡啶)乙氧基]苄基]-2,4-噻唑烷二酮;吡格列酮;5-{4-[2-(5-乙基-2-吡啶基)乙氧基]苄基}-2,4-噻唑烷二酮;匹格列酮碱;吡格列酮D4;匹格列酮(标准品);(±)-5-[[4-[2-(5-乙基-2-吡啶基)乙氧基]苯基]甲基]-2,4-噻唑啉二酮;5-(4-(2-(5-乙基吡啶-2-基)乙氧基)苄基)噻唑烷-2,4-二酮
英文名称	Pioglitazone
英文别名	Pioglitazone;5-[4-[2-(5-ETHYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL-2,4-THIAZOLIDINEDIONE;5-(4-[2-(5-ETHYL-PYRIDIN-2-YL)-ETHOXY]-BENZYL)-THIAZOLIDINE-2,4-DIONE;5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;Pioglitazone free base;Pioglitazone and its intermeidates;PIOGLITAZONE HCL(5-[[4-[2-(5-ETHYLPYRIDIN-2-YL)ETHOXY]PHENYL]METHYL]THIAZOLIDINE-2,4-DIONE, HCL);PINEPOLLENKY-18;2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-;5-((4-(2-(5-ETHYL-2-PYRIDINYL)ETHOXY)PHENYL)METHYL)-2,4-THIAZOLIDINEDIONE, HCL;U 72107;PINEPOLLEN;Pioglitazone (Actos);5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione;5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl]thiazolidine-2,4-dione;2,4-Thiazolidinedione,5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]Methyl]-;Actos;Pioglitazona;Pioglitazonum;Glustin;Zactos;Pioglitazonum [INN-Latin];Pioglitazona [INN-Spanish];Duetact;Pioglitazone [INN:BAN];Pioglitazone [BAN:INN];5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione;5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione;Actos (TN);C19H20N2O3S;5-[4-[2-(5-ETHYL-2-PYRIDYL)ETHOXY]BENZYL]-2,4-THIAZOLIDINEDIONE;U 72107A;5-[[4-[2-(5-ethyl;5-[4-[2-(5-ETH
Cas No.	111025-46-8
分子式	C₁₉H₂₀N₂O₃S
分子量	356.44
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Pioglitazone (U 72107) 是一种具有口服活性的选择性 PPARγ (peroxisome proliferator-activated receptor) 激动剂，高亲和力结合到 PPARγ 配体结合域，作用于人和鼠 PPARγ 的 EC₅₀ 分别为 0.93 和 0.99 μM。Pioglitazone 可用于糖尿病研究。

生物活性

Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC 50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research.

性状

Solid

IC50 & Target[1][2]

hPPARγ 0.93 μM (EC50) mouse PPARγ 0.99 μM

体外研究(In Vitro)

Pioglitazone (0.5 or 1 μM, 5 days) can completely prevent AGEs (advanced glycation end-products)-induced β-cell necrosis and the increase of caspase-3 thereby avoiding the impaired viability caused by AGEs in pancreatic beta cell line HIT-T15.
Pioglitazone (1 μM, 1 h) can stimulate insulin secretion induced by low glucose concentration and attenuate the GSSG/GSH ratio in cells cultured with AGEs.
has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Pioglitazone (oral gavage, 10 or 30 mg/kg, once daily, 14 days) can induce improvements in insulin resistance and diabetes that may be lipocalin-dependent in the liver but not in skeletal muscle.
Pioglitazone (oral gavage, 10 mg/kg, once daily, 4 weeks) can significantly reduce body weight (BW), cardiac hypertrophy, elevated blood glucose levels and improve the associated dyslipidemia.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve
[2]. Puddu A, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177(1-3):79-84.

溶解度数据	In Vitro: DMSO : 40 mg/mL (112.22 mM; ultrasonic and warming and heat to 60°C)配制储备液

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Data Sheet

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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