L-Palmitoylcarnitine chloride|18877-64-0|-陌孚医药/Medlife

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L-Palmitoylcarnitine chloride

目录号: PL09984 纯度: ≥98.0%

CAS No. :18877-64-0

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中文名称	L-Palmitoylcarnitine chloride
中文别名	L-氯化棕榈酰肉碱;5-溴-3-氰基噻吩;small>-肉碱盐酸盐;棕榈酰-L<;(R)-3-(十六酰氧基)-4-(三甲基铵)丁酸盐盐酸盐;(R)-3-(棕榈酰氧基)-4-(三甲基铵)丁酸盐盐酸盐;L-棕榈酰基肉碱;左旋棕榈酰肉碱盐酸盐
英文名称	L-Palmitoylcarnitine chloride
英文别名	1-Propanaminium,3-carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-, chloride (1:1), (2R)-;PALMITOYL-L-CARNITINE CHLORIDE;Palmitoyl-L-carnitine Hydrochloride;O-Palmitoyl-L-carnitine chloride;(R)-3-(Hexadecanoyloxy)-4-(trimethylammonio)butyrate Hydrochloride;(R)-3-(Palmitoyloxy)-4-(trimethylammonio)butanoate Hydrochloride;Einecs 242-642-6;L-CARNITINE:HCL, O-PALMITOYL;L-Palmitoylcarnitine chloride;HEXADECANOYL-L-CARNITINE CHLORIDE;(R)-[3-carboxy-2-[(1-oxohexadecyl)oxy]propyl]trimethylammonium chloride;1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(1-oxohexadecyl)oxy-, chloride, (2R)-;Palmitoyl-L-carnitine chloride≥ 99% (TLC);O-PALMITOYL-L-CARNITINE CHLORIDE;Palmitoyl-L-carnitine hydrochloride
Cas No.	18877-64-0
分子式	C₂₃H₄₆NO₄+^.Cl-
分子量	436.07
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	L-Palmitoylcarnitine chloride是一种长链酰基肉碱和脂肪酸代谢产物，在缺血期间积聚于肌膜并扰乱膜脂环境。L-Palmitoylcarnitine chloride 通过与 Kir6.2 的相互作用抑制 K_ATP 通道活性，而不影响单通道电导。
生物活性	L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits K ATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.
性状	Solid
IC50 & Target[1][2]	Kir6.2 Human Endogenous Metabolite
体外研究(In Vitro)	L-Palmitoylcarnitine (1 μM) inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC50 fell from 62 to 30 μM). Modulation of the membrane lipid environment caused by L-Palmitoylcarnitine alters the KATP channel function mainly through the interaction with endogenous PI cascade, especially PIP2. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441(2-3):200-207.

溶解度数据	In Vitro: DMSO : 50 mg/mL (114.66 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (insoluble)配制储备液

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