Sotalol hydrochloride|959-24-0|(盐酸索他洛尔; MJ 1999)-陌孚医药/Medlife

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Sotalol hydrochloride (Synonyms: 盐酸索他洛尔; MJ 1999)

目录号: PL09994 纯度: ≥99%

CAS No. :959-24-0

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中文名称	Sotalol hydrochloride
中文别名	盐酸索他洛尔;4'-(1-羟基-2-异丙胺乙基)甲磺酸苯胺盐酸盐;盐酸索他洛尔 USP标准品;盐酸索他洛尔标准品;盐酸索他洛尔,USP;盐酸心得怡 EP标准品;N-[4-[1-羟基-2-(异丙基氨基)乙基]苯基]甲盐酸
英文名称	Sotalol hydrochloride
英文别名	(+)-sotalol hydrochloride;Sotalol Hydrochloride;4-(1-hydroxy-2-isopropylaminoethyl)methanesulphonanilide hydrochloride;Sotalol HCl;(+/-)-SOTALOL HYDROCHLORIDE;(±)-Sotalol hydrochloride;Methanesulfonamide, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-, hydrochloride;N-{4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl}methanesulfonamide;Sotalol (hydrochloride);Sotalol Hydrochlorid;N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride;4'-(1-Hydroxy-2-isopropylaminoethyl)methanesulphonanilide hydrochloride;Methanesulfonamide, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-, monohydrochloride (9CI);Methanesulfonanilide, 4′-[1-hydroxy-2-(isopropylamino)ethyl]-, monohydrochloride (8CI);4′-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide hydrochloride;4′-[2-(Isopropylamino)-1-hydroxyethyl]methanesulfonanilide hydrochloride;4′-[2-(Isopropylamino)-1-hydroxyethyl]methanesulfonanilide monohydrochloride;DL-MJ 1999;D;L;Betapace;Darob;dl-Sotalol hydrochloride;MJ 1999;N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide hydrochloride;N-Isopropyl-β-(4-methanesulfonamidophenyl)ethanolamine hydrochloride;Sotacor;Sotalex;Sotalol hydrochloride
Cas No.	959-24-0
分子式	C₁₂H₂₁ClN₂O₃S
分子量	308.82
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Sotalol hydrochloride (MJ 1999) 是一种口服有效，非选择性 β-肾上腺素受体阻断剂。Sotalol hydrochloride 具有抗心律失常作用，可用于小儿心律失常的研究。Sotalol hydrochloride 阻断 β受体和钾KCNH2 通道，具有抗抗癫痫作用。
生物活性	Sotalol hydrochloride (MJ 1999) is an orally active, non-selective β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent.
性状	Solid
IC50 & Target[1][2]	β-adrenergic receptor; Potassium channels
体内研究(In Vivo)	Sotalol hydrochloride (MJ 1999) is an antiarrhythmic agent.Sotalol at doses of up to 100 mg/kg does not affect the electroconvulsive threshold. Applied at doses of 80-100 mg/kg, sotalol hydrochloride does not affect the antielectroshock action of Oxcarbazepine, Lamotrigine, Pregabalin, or Topiramate. Sotalol hydrochloride alone and in combinations with antiepileptics impairs neither motor performance nor long-term memory. Sotalol hydrochloride (100 mg/kg) significantly decreases the brain concentration of Lamotrigine, increases those of Oxcarbazepine and Topiramate, and does not affect the level of Pregabalin. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Marta Reyes-Corral, et al. Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines. J Pharmacol Exp Ther. 2019 Apr;369(1):152-162. [2]. Xiaomei Li, et al. Pediatric Dosing of Intravenous Sotalol Based on Body Surface Area in Patients with Arrhythmia. Pediatr Cardiol. 2017 Oct;38(7):1450-1455.

溶解度数据	In Vitro: DMSO : 100 mg/mL (323.81 mM; Need ultrasonic)H₂O : ≥ 100 mg/mL (323.81 mM)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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