LMPTP inhibitor 1 dihydrochloride|2310135-46-5|-陌孚医药/Medlife

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LMPTP inhibitor 1 dihydrochloride

目录号: PL09603 纯度: ≥99%

CAS No. :2310135-46-5

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中文名称	LMPTP inhibitor 1 dihydrochloride
英文名称	LMPTP inhibitor 1 dihydrochloride
英文别名	LMPTP Inhibitor 1 dihydrochloride;LMPTP Inhibitor 1 2HCl;LMPTP INHIBITOR 1 (dihydrochloride);LMPTP2HCL;BCP30155;AK00780584
Cas No.	2310135-46-5
分子式	C₂₈H₃₈Cl₂N₄O
分子量	517.53
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	LMPTP INHIBITOR 1 (dihydrochloride) 是一种选择性的低分子量蛋白酪氨酸磷酸酶 (LMPTP) 抑制剂，能够抑制 LMPTP-A 的活性，IC₅₀ 值为 0.8 μM。
生物活性	LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC 50 of 0.8 μM LMPTP-A.
性状	Solid
IC50 & Target[1][2]	IC50: 0.8 μM (LMPTP-A)
体外研究(In Vitro)	LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50 of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Stanford SM1, et al. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun;13(6):624-632.

溶解度数据	In Vitro: DMSO : ≥ 64 mg/mL (123.66 mM)H₂O : 50 mg/mL (96.61 mM; Need ultrasonic)

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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