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L-Palmitoylcarnitine-d3 (hydrochloride)

目录号: PL09931 纯度: ≥99%

L-Palmitoylcarnitine-d3 (hydrochloride) 是 L-Palmitoylcarnitine hydrochloride 的氘代物。L-Palmitoylcarnitine hydrochloride 是一种长链酰基肉碱和脂肪酸代谢产物，在缺血期间积聚于肌膜并扰乱膜脂环境。L-Palmitoylcarnitine hydrochloride 通过与 Kir6.2 的相互作用抑制 KATP 通道活性，而不影响单通道电导。

CAS No. :1334532-26-1

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中文名称	L-Palmitoylcarnitine-d3 (hydrochloride)
中文别名	L-氯化棕榈酰肉碱-D3氘代内标;L-氯化棕榈酰肉碱-D3;十六酰基-L-肉碱-d3盐酸盐(N-甲基-d3);十六烷酰基-L-肉碱 d3 （盐酸盐）;L-十六碳酰肉碱盐酸盐-D3;十六烷酰基-L-肉碱-[D3] HCL;棕榈酰-L-左旋肉碱-[D3]盐酸盐;左卡尼汀:HCL, O-PALMITOYL;十六烷酰基-L-肉碱-[D3]盐酸盐;左旋肉碱:盐酸盐, O-棕榈酰 (N-甲基-D3, 98%);棕榈酰左旋肉碱-D3盐酸盐
英文名称	L-Palmitoylcarnitine-d3 (hydrochloride)
英文别名	Hexadecanoyl-L-carnitine-d3?HCl (N-methyl-d3);Palmitoyl-L-carnitine-d3 Hydrochloride;Palmitoyl-L-carnitine-d3Hydrochloride;CID 131872269;L-Palmitoylcarnitine-d3 (hydrochloride);(3R)-4-[dimethyl(trideuteriomethyl)azaniumyl]-3-hexadecanoyloxybutanoate:hydrochloride;Palmitoyl-L-carnitine-d3 HCl (N-methyl-d3);Palmitoyl-L-carnitine-d3 (chloride);L-CARNITINE:HCL, O-PALMITOYL (N-METHYL-D3, 98%);O-Palmitoyl-(N-methyl-D3)-L-Carnitine HCl salt;Hexadecanoyl-L-carnitine-d3 Hydrochloride
Cas No.	1334532-26-1
分子式	C₂₃H₄₆ClNO₄
分子量	439.09
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	L-Palmitoylcarnitine-d3 (hydrochloride) 是 L-Palmitoylcarnitine hydrochloride 的氘代物。L-Palmitoylcarnitine hydrochloride 是一种长链酰基肉碱和脂肪酸代谢产物，在缺血期间积聚于肌膜并扰乱膜脂环境。L-Palmitoylcarnitine hydrochloride 通过与 Kir6.2 的相互作用抑制 KATP 通道活性，而不影响单通道电导。

产品详情	L-Palmitoylcarnitine-d₃ (hydrochloride) 是 L-Palmitoylcarnitine hydrochloride 的氘代物。L-Palmitoylcarnitine hydrochloride 是一种长链酰基肉碱和脂肪酸代谢产物，在缺血期间积聚于肌膜并扰乱膜脂环境。L-Palmitoylcarnitine hydrochloride 通过与 Kir6.2 的相互作用抑制 K_ATP 通道活性，而不影响单通道电导。
生物活性	L-Palmitoylcarnitine-d 3 (hydrochloride) is the deuterium labeled L-Palmitoylcarnitine hydrochloride. L-Palmitoylcarnitine hydrochloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine hydrochloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].
性状	Solid
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441(2-3):200-207.

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[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441(2-3):200-207.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

L-Palmitoylcarnitine-d3 (hydrochloride)

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