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Phe-Met-Arg-Phe amide trifluoroacetate

目录号: PL09401 纯度: ≥98.0%

Phe-Met-Arg-Phe amide trifluoroacetate 是一种神经肽，在肽能神经元中激活 K⁺ 电流，ED50 为 23 nM，这种作用具有剂量依赖性。

CAS No. :159237-99-7

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中文名称	Phe-Met-Arg-Phe amide trifluoroacetate
英文名称	Phe-Met-Arg-Phe amide trifluoroacetate
英文别名	Phe-Met-Arg-Phe amide trifluoroacetate;Phe-Met-Arg-Phe amide (trifluoroacetate)
Cas No.	159237-99-7
分子式	C₃₃H₄₄F₆N₈O₈S
分子量	826.81
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
详情描述	Phe-Met-Arg-Phe amide trifluoroacetate 是一种神经肽，在肽能神经元中激活 K⁺ 电流，ED50 为 23 nM，这种作用具有剂量依赖性。

产品详情	Phe-Met-Arg-Phe amide trifluoroacetate 是一种神经肽，在肽能神经元中激活 K⁺ 电流，ED₅₀ 为 23 nM，这种作用具有剂量依赖性。
生物活性	Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K current, with ED 50 of 23 nM in the peptidergic caudodorsal neurons.
性状	Solid
IC50 & Target[1][2]	ED50: 23 nM (K current)
体外研究(In Vitro)	In the molluscan central nervous system, Phe-Met-Arg-Phe amide (FMRFa) acts on K channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe amide activates a novel K current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels. Phe-Met-Arg-Phe amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe amide (FMRF-NH2) (1 and 10 μM) is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Phe-Met-Arg-Phe amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	FMRF-NH2
Sequence	Phe-Met-Arg-Phe-NH2
参考文献	[1]. Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. [2]. Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82.

溶解度数据	In Vitro: DMSO : 100 mg/mL (120.95 mM; Need ultrasonic)H₂O : 20 mg/mL (24.19 mM; Need ultrasonic)配制储备液

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[1]. Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28.
[2]. Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Phe-Met-Arg-Phe amide trifluoroacetate

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