Rimtuzalcap|2167246-24-2|-陌孚医药/Medlife

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Rimtuzalcap

目录号: PL09160 纯度: ≥99%

CAS No. :2167246-24-2

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PL09160-100mg	100mg	¥18965.00	请登录
PL09160-200mg	200mg	询价	询价
PL09160-500mg	500mg	询价	询价

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中文名称	Rimtuzalcap
英文名称	Rimtuzalcap
英文别名	Rimtuzalcap;USO2D5J77R;Rimtuzalcap [INN];Rimtuzalcap [USAN];WHO 11140
Cas No.	2167246-24-2
分子式	C₁₈H₂₄F₂N₆O
分子量	378.42
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情

Rimtuzalcap (CAD-1883) 是首创的，选择性的小电导钙激活钾通道 (SK 通道) 正变构调节剂。Rimtuzalcap 可用于运动障碍的研究，包括特发性震颤 (ET) 和脊髓小脑性共济失调 (SCA)。

生物活性

Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA).

性状

Solid

体外研究(In Vitro)

Rimtuzalcap (Compound 1) is a small molecule modulator of potassium ion channels showing great therapeutic potential for treating a variety of diseases characterized by dysfunction of potassium ion channels and dysfunction from other causes which influence these potassium channels. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Rimtuzalcap (CAD-1883) reduces the firing rate of Purkinje cells by approximately 40%, consistent with the anticipated therapeutic mechanism of positive allosteric modulation of SK channels. Sequential bath application of 1 or 3 μM CAD-1883 results in a partial reversal of the increased coefficient of variation of the interspike interval which is seen in cerebellar slices from 11-month-old spinocerebellar ataxia-2 58Q mice. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

ClinicalTrial

参考文献

[1]. Crystalline forms of potassium channel modulators. WO2020086456A1.

溶解度数据	In Vitro: DMSO : 250 mg/mL (660.64 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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