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产品总数：60959
| 中文名称 |
Quinacrine dihydrochloride
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|---|---|
| 中文别名 |
盐酸阿的平;盐酸米帕林;二盐酸奎吖因水合物;喹吖因 二盐酸盐;Quinacrine Dihydrochloride Hydrate 二盐酸奎吖因水合物;喹吖因二盐酸;米帕林盐酸盐;疟疾平;6-氯-9-(4-二乙基氨基-1-甲基丁基)氨基-2-甲氧基吖啶二盐酸盐;二盐酸喹吖因;喹吖因二盐酸盐（阴凉）;6-氯-9-(4-二乙氨基-1-甲基丁氨基)-2-甲氧基吖啶 二盐酸盐;米帕林 二盐酸盐;阿的平 二盐酸盐;奎纳克林二盐酸盐;阿的平盐酸盐;喹吖因二盐酸盐;阿的平
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| 英文名称 |
Quinacrine dihydrochloride
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| 英文别名 |
quinacrine dihydrochloride;mepacrine hydrochloride;Quinacrine, DiHCl;Quinacrine Dihydrochloride Hydrate;Quinacrine dihydrochloride ( SN 390, Atabrine® dihydrochloride, Mepacrine dihydrochoride);QUINACRINE DIHYDROCHLORIDE CRYSTALLINE;1,4-Pentanediamine,N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, hydrochloride (1:2);Mepacrine dihydrochloride;SN-390;6-Chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxyacridine dihydrochloride;866RP;Acrichin dihydrochloride;Atabrine hydrochloride;Atebrin;Atebrine;Atebrine hydrochloride;Quinacrine 2HCl;Quinacrine hydrochloride;Chemiochin;Metoquin;Crinodora;Metoquine;Pentilen;Palusan;Metochin;Malaricida;Italchin;Palacrin;Methoquine;Mecryl;Atebrin hydrochloride;Erion;Quinacrine (dihydrochloride);Chinacrin hydrochloride;Quinacrine hydrochloride anhydrous;l-Atabrine 2HCl;d-Atabrine 2HCl;Atabrine dihydrochloride;SN 390;S.N. 390;2-Methoxy-6-chloro-9-(4-d;SN-390 dihydrochloride;Quinacrine dihydrochloride
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| Cas No. |
69-05-6
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| 分子式 |
C23H32Cl3N3O
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| 分子量 |
472.88
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| 包装储存 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| 产品详情 |
Quinacrine (Mepacrine) dihydrochloride 是一种有效的，具有口服活性的抗疟剂 (antimalarial)，在体内外均具有抗肿瘤作用。Quinacrine dihydrochloride 抑制 NF-κB 并激活 p53 信号转导，诱导肿瘤细胞发生凋亡 (apoptosis)。
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| 生物活性 |
Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis.
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| 性状 |
Solid
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| 体外研究(In Vitro) |
Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells.Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway.Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis . has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| ClinicalTrial |
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| 参考文献 |
[1]. Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64.[2]. Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46.
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| 溶解度数据 |
In Vitro: DMSO : ≥ 44 mg/mL (93.05 mM)H2O : 13.89 mg/mL (29.37 mM; Need ultrasonic)
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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