Lorvotuzumab (Anti-NCAM1/CD56 Reference Antibody (lorvotuzumab)) is a humanized monoclonal antibody that binds CD56 (NCAM1). Lorvotuzumab can be used to synthesize an ADC compound, Lorvotuzumab mertansine.
体外研究(In Vitro)
Lorvotuzumab mertansine (IMGN901) 是一种 ADC,可通过二硫键连接强效抗有丝分裂 (DM1) 与 CD56 靶向抗体 (Lorvotuzumab)。 Lorvotuzumab mertansine 抗肾母细胞瘤、横纹肌肉瘤和神经母细胞瘤。 has not independently confirmed the accuracy of these methods. They are for reference only.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. James I Geller, et al. ADVL1522: A phase 2 study of lorvotuzumab mertansine (IMGN901) in children with relapsed or refractory wilms tumor, rhabdomyosarcoma, neuroblastoma, pleuropulmonary blastoma, malignant peripheral nerve sheath tumor, or synovial sarcoma-A Childrens Oncology Group study. Cancer. 2020 Dec 15;126(24):5303-5310.
[1]. James I Geller, et al. ADVL1522: A phase 2 study of lorvotuzumab mertansine (IMGN901) in children with relapsed or refractory wilms tumor, rhabdomyosarcoma, neuroblastoma, pleuropulmonary blastoma, malignant peripheral nerve sheath tumor, or synovial sarcoma-A Childrens Oncology Group study. Cancer. 2020 Dec 15;126(24):5303-5310.