Boc-Leu-Gly-Arg-AMC|65147-09-3|-陌孚医药/Medlife

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Boc-Leu-Gly-Arg-AMC

目录号: PL05942 纯度: ≥98%

Boc-Leu-Gly-Arg-AMC 是一种转化酶的荧光 AMC 底物，可用于酶促测定。

CAS No. :65147-09-3

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中文名称	Boc-Leu-Gly-Arg-AMC
英文名称	Boc-Leu-Gly-Arg-AMC
英文别名	L-Argininamide,N-[(1,1-dimethylethoxy)carbonyl]-L-leucylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-(9CI);Boc-Leu-Gly-Arg-AMC;N-ALPHA-T-BOC-L-LEU-GLY-L-ARG-4-METHYLCOUMARYL-7-AMIDE;tert-butyl N-[1-[[2-[[5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]carbamate;Boc-Leu-Gly-Arg-Amc Acetate Salt;Boc-Leu-Gly-Arg-Mca;tert-butyl N-[(2S)-1-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]carbamate;Boc-LGR-MCA;Boc-Leu-Gly-Arg-4-methyl-coumaryl-7-amide;tert-butyl (S)-1-(2-((S)-5-guanidino-1-(4-methyl-2-oxo-2H-chromen-7-ylamino)-1-oxopentan-2-ylamino)-2-oxoethylamino)-4-methyl-1-oxopentan-2-ylcarbamate
Cas No.	65147-09-3
分子式	C₂₉H₄₃N₇O₇
分子量	601.69
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	Boc-Leu-Gly-Arg-AMC 是一种转化酶的荧光 AMC 底物，可用于酶促测定。
生物活性	Boc-Leu-Gly-Arg-AMC is a fluorogenic AMC substrate for the convertases. Boc-Leu-Gly-Arg-AMC can be used in enzymatic assays.
性状	Solid
体外研究(In Vitro)	To demonstrate the presence in the abdominal gland of proteolytic enzymes capable of generating Sodefrin, an enzymatic assay was developed using Boc-Leu-Gly-Arg-AMC as synthetic substrate. A crude extract of the abdominal gland hydrolyzed Boc-Leu-Gly-Arg-AMC to liberate 7-amino-4- methylcoumarin, suggesting that enzymes that generate sodefrin from its precursor molecule are present in the gland. The activity in the extract for cleaving Boc-Leu-Gly-Arg-AMC is optimal at pH 9.0 and 45 ℃. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	Boc-LGR-AMC
Sequence	Boc-Leu-Gly-Arg-AMC
参考文献	[1]. Nakada T, et al. Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster, that generate sodefrin from its biosynthetic precursor. Zoolog Sci. 2007 May;24(5):521-4. [2]. Yumiko Obayashi, et al. Proteolytic enzymes in coastal surface seawater: Significant activity of endopeptidases and exopeptidases Limnol. Oceanogr., 50(2), 2005, 722-726.

溶解度数据	In Vitro: DMSO : 100 mg/mL (166.20 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (insoluble)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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