cis-4-Hydroxy-D-proline hydrochloride|77449-94-6|-陌孚医药/Medlife

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cis-4-Hydroxy-D-proline hydrochloride

目录号: PL05127

CAS No. :77449-94-6

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中文名称	cis-4-Hydroxy-D-proline hydrochloride
中文别名	顺式-4-羟基-D-脯氨酸盐酸盐;顺式-4-羟基-D-脯氨酸盐酸盐(3周-1个月);顺式-(D)-4-羟基脯氨酸盐酸盐;顺式-D-羟脯氨酸盐酸盐;顺式-4-羟基-脯氨酸盐酸盐;(2R,4R)-4-羟基吡咯烷-2-羧酸盐酸盐;顺-4-羟基-D-脯氨酸（盐酸盐形式的）;顺式-(D)-4-羟基脯氨酸盐酸盐顺式-D-羟脯氨酸盐酸盐顺式-4-羟基-脯氨酸盐酸盐
英文名称	cis-4-Hydroxy-D-proline hydrochloride
英文别名	Cis-4-Hydroxy-D-proline hydrochloride;CIS-4-HYDROXY-D-PROLINE HCL;(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride;cis-4-Hydroxy-D-proline hydrochloride ((2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride);cis-4-Hydro×y-D-proline hydrochloride;(2R,4R)-4-hydroxyproline hydrochloride;(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride;(4-(2-chlorophenyl)thiazol-2-yl)Methanol;Cis-4-OH-D-pro-OH HCl;cis-D-Hyp-OH.HCl;D-Proline, 4-hydroxy-,hydrochloride (1:1), (4R)-
Cas No.	77449-94-6
分子式	C₅H₉NO₃^.HCl
分子量	167.59
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	cis-4-Hydroxy-D-proline (hydrochloride) 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。cis-4-Hydroxy-D-proline (hydrochloride) 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。
生物活性	cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
性状	Solid
IC50 & Target[1][2]	Non-cleavable
体外研究(In Vitro)	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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