SMCC|64987-85-5|-陌孚医药/Medlife

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SMCC

目录号: PL05047 纯度: ≥99%

CAS No. :64987-85-5

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中文名称	SMCC
中文别名	4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯;4-(N-马来酰亚胺甲基)环己烷羧酸-N-琥珀酰亚胺酯;1-苯基环己烷甲胺;N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate 4-(N-马来酰亚胺甲基)环己烷羧酸-N-琥珀酰亚胺酯;SMCC 4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯;4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺;4-(N-马来酰亚胺基甲基)环己烷羧酸N-羟基琥珀酰亚胺酯;N-琥珀酰亚胺基4-(马来酰亚胺基甲基)环己烷羧酸酯;4-(N-马来酰亚胺基甲基)环己烷羧酸N-羟基琥珀酰亚胺酯 (SMCC)
英文名称	SMCC
英文别名	2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylate;4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester;N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate;N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate;N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate;N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate;Smcc;SMCC [4-(N-MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLIC ACID N-HYDROXYSUCCINIMIDE ESTER];Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate;4-(N-Maleimidomethyl)cyclohexanecarboxylic Acid N-Succinimidyl Ester;N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate(SMCC);TRANS-4-(MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLIC ACID-NHS;trans-2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylate;N-(4-Carboxycyclohexylmethyl)maleimide N-hydroxysuccinimide ester;B357P1G1IF;succ;SMCCcrosslinker;SMCC
Cas No.	64987-85-5
分子式	C₁₆H₁₈N₂O₆
分子量	334.32
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

SMCC 是一种蛋白质交联剂。SMCC 接合抗原耦合脾脏细胞来诱导抗原特异性免疫反应。

生物活性

SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.

性状

Solid

体外研究(In Vitro)

SMCC or sulfo-SMCC can use to conjugate keyhole limpet hemocyanin (KLH) and ovalbumin (OVA). In the the conjugation system, 300 μl KLH or OVA (3 mg) and 30 μl SMCC or Sulfo-SMCC (the final concentration of 0.1 mM) are added in PBS with final volume of 3 ml.
has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Using the SMCC-conjugation method is able to induce potent immune responses to whole protein or peptide antigens by injection of antigen-coupled syngeneic splenic mononuclear cells in mice.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Guo Y, et al. Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens. Int Immunopharmacol. 2016 Feb;31:158-68.

溶解度数据	In Vitro: DMSO : 25 mg/mL (74.78 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (ultrasonic) (insoluble)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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