Parecoxib|198470-84-7|(帕瑞昔布; SC 69124)-陌孚医药/Medlife

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Parecoxib (Synonyms: 帕瑞昔布; SC 69124)

目录号: PL04724 纯度: ≥98%

CAS No. :198470-84-7

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中文名称	Parecoxib
中文别名	帕瑞昔布;1-十二烯-1,2-13C2;WITEGANS039帕瑞昔布标准品;伐地考昔杂质J;帕瑞考昔;帕瑞考昔标准品;帕瑞昔布标准品;帕瑞昔布杂质;帕瑞昔布杂质对照品;N-[[4-(5-甲基-3-苯基异恶唑-4-基)苯基]磺酰基]丙酰胺;帕瑞昔布钠杂质I;帕瑞昔布钠杂质J;帕瑞昔布钠杂质 W;帕瑞昔布钠杂质,PR-12-I;4-(5-甲基-3-苯基-异噁唑基)-N-丙酰基苯磺酰胺;N-[[4-(5-甲基-3-苯基-4-异恶唑基)苯基]磺酰基]丙酰胺;N-[[4-(5-甲基-3-苯基-4-异恶唑基)苯基]磺酰基]丙酰胺盐;N-{[4-(5-甲基-3-苯基-4-异恶唑-4-基)苯基]磺酰基}丙酰胺
英文名称	Parecoxib
英文别名	Parecoxib;Dynastat;Parocoxib;SC 69124;N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propionamide;N-[4-(5-methyl-3-phenyl-oxazol-4-yl)phenyl]sulfonylpropanamide;N-{[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonyl}propanamide;Parecoxib [USAN:INN:BAN];Propanamide, N-((4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)-;UNII-9TUW81Y3CE;N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide;N-{[4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl]sulfonyl}propionamide;N-[[4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl]sulfonyl]propionamide (This product is unavailable in the U.S.);N-[4-(5-Methyl-3-phenyloxazol-4-yl)phenyl]sulfonylpropanamide;Valus-P;Vorth-P;Valdecoxib Impurity J;Parecoxib SodiuM IMpurity W;Parecoxib SodiuM iMpurity PR-12-I;N-(4-(5-Methyl-3-phenylisoxazol-4-yl)phenylsulfonyl)propionaMide
Cas No.	198470-84-7
分子式	C₁₉H₁₈N₂O₄S
分子量	370.42
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Parecoxib (SC 69124) 是一种选择性强、口服活性强的 COX-2 抑制剂，Valdecoxib (HY-15762) 的前药。Parecoxib Sodium 是一种非甾体抗炎试剂 (NSAID)，可抑制前列腺素(PG) 的合成。动物实验中，Parecoxib Sodium 可用于缓解术后急性疼痛和骨关节炎、类风湿关节炎等慢性炎症症状。

生物活性

Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the prodrug of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.

性状

Solid

IC50 & Target[1][2]

COX-2

体外研究(In Vitro)

Parecoxib (0-200?μM; 24-48 hours) inhibits the cell proliferation of GBM cells in a dose-dependent manner in GBM cells.
Parecoxib (200?μM; 24-48 hours) results in a decreasee migratory ability of U343 cells than PBS-treated group. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay-tbl">

体内研究(In Vivo)

Parecoxib (intraperitoneal injection; 2.5, 5.0 or 10 mg/kg; once a day; 21 days) does not affect locomotor activity in the elevated plus-maze test, and Parecoxib at 5 and 10 mg/kg shows higher levels of percentage of time spent in the open arms.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Jun Tang, et al. Effect of parecoxib, a novel intravenous cyclooxygenase type-2 inhibitor, on the postoperative opioid requirement and quality of pain control. Anesthesiology
[2]. J L Mateos, et al.[Selective inhibitors of cyclooxygenase-2 (COX-2), celecoxib and parecoxib: a systematic review]. Drugs Today (Barc). 2010 Feb;46 Suppl A:1-25.

溶解度数据	In Vitro: DMSO : ≥ 50 mg/mL (134.98 mM)配制储备液

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