MDTF is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
性状
Solid
体外研究(In Vitro)
MDTF (50?μM) increases hydrophilic character by substitution of a cyclohexyl ring and a MD-based FRET probe incubates in human plasma has a considerably higher self-stabilization rate compared to the MCC-based probe. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Dovgan I, et, al. 2-(Maleimidomethyl)-1,3-Dioxanes (MD): a Serum-Stable Self-hydrolysable Hydrophilic Alternative to Classical Maleimide Conjugation. Sci Rep. 2016 Aug 9;6:30835.
溶解度数据
In Vitro: DMSO : 100 mg/mL (203.54 mM; ultrasonic and warming and heat to 60°C)配制储备液