Isoflupredone acetate (Synonyms: 醋酸异氟泼尼松)
目录号: PL03391 纯度: ≥98%
Isoflupredone acetate 是一种具有抗炎活性的皮质类固醇。Isoflupredone acetate 可用于研究牛、马、猪等动物的酮症、肌肉骨骼疾病、过敏、感染、炎症等疾病。
CAS No. :338-98-7
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中文名称
Isoflupredone acetate
中文别名
醋酸异氟泼尼松;(11β)-21-(乙酰氧基)-9-氟代-11, 17-二羟基-孕-1,4-二烯-3,20-二酮;9-氟醋酸泼尼松龙;9-氟泼尼龙醋酸酯,氟泼尼龙醋酸酯;Isoflupredone醋酸;醋酸异氟泼尼龙;醋酸异氟泼尼松,In-house Standard;氟醋酸泼尼松;氟泼尼龙醋酸酯;乙酸异氟泼尼龙 USP标准品;异氟泼尼松龙醋酸酯;9氟醋酸泼尼松龙;醋酸氟氢泼尼松
英文名称
Isoflupredone acetate
英文别名
Isoflupredone acetate;21-Acetoxy-9-fluoro-11b,17-dihydroxypregna-1,4-diene-3,20-dione;[2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Cas No.
338-98-7
分子式
C23H29FO6
分子量
420.47
包装储存
Powder -20°C 3 years;In solvent -80°C 6 months
产品详情
Isoflupredone acetate 是一种具有抗炎活性的皮质类固醇。Isoflupredone acetate 可用于研究牛、马、猪等动物的酮症、肌肉骨骼疾病、过敏、感染、炎症等疾病。
生物活性
Isoflupredone acetate is a corticosteroids with anti-inflammatory activity. Isoflupredone acetate can be used for research ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases in cows, horse, pigs, et al..
性状
Solid
体外研究(In Vitro)
Isoflupredone acetate (10, 10, or 10 M; 48 or 96 h)mitigates the inflammatory and catabolic effects of IL-1β in synovial and osteochondral explants (from equine cadavers) to a greater extent in low concentrations (10 M and 10 M) than the high concentration (10 M). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to faster Mannheimia haemolytica-infected clinical improvement when co-treated with Oxytetracycline (HY-B0275). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;In solvent -80°C 6 months
参考文献
[1]. Trahan RA, et al. In vitro effects of three equimolar concentrations of methylprednisolone acetate, triamcinolone acetonide, and isoflupredone acetate on equine articular tissue cocultures in an inflammatory environment. Am J Vet Res. 2018 Sep;79(9):933-940.
[2]. Hewson J, et al. Impact of isoflupredone acetate treatment on clinical signs and weight gain in weanling heifers with experimentally induced Mannheimia haemolytica bronchopneumonia. Am J Vet Res. 2011 Dec;72(12):1613-21.
溶解度数据
In Vitro: DMSO : 125 mg/mL (297.29 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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