TAK-779|229005-80-5|(Takeda 779)-陌孚医药/Medlife

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TAK-779 (Synonyms: Takeda 779)

目录号: PL03390 纯度: ≥99%

CAS No. :229005-80-5

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中文名称	TAK-779
中文别名	TAK-779
英文名称	TAK-779
英文别名	2H-Pyran-4-aminium,N-[[4-[[[6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-,chloride (1:1);2H-Pyran-4-aminium,N-[[4-[[[6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N;N,N-Dimethyl-N-[4-({[2-(4-methylphenyl)-6,7-dihydro-5H-benzo[7]an nulen-8-yl]carbonyl}amino)benzyl]tetrahydro-2H-pyran-4-aminium ch loride;TAK 779;TAK 799;TAK-779;Takeda 779;N,N-Dimethyl-N-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5H-benzohepten-8-yl]carbonyl]amino]benzyl]tetrahydro-2H-pyran-4-aminium chloride;TAK-799;BQW1Y9KIIP;N,N-Dimethyl-N-(4-(((2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-yl)carbonyl)amino)benzyl)tetrahydro-2H-pyran-4-aminium chloride;2H-Oyran-4-aminium, N-((4-(((6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl)carbonyl)amino)phenyl)methyl)tetrahydro-N,N-dimethyl-;2H-Pyran-4-aminium, N,N-dimethyl-N-(4-(((2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-yl)carbonyl)amino)benzyl)tetrahydro-, chloride;C33H39N;Chloride;chloride(TAK-779);TAK779;TAK779;TAK 799;Takeda 779;N,N-Dimethyl-N-[4-({[2-(4-methylphenyl)-6,7-dihydro-5H-benzo[7]annulen-8-yl]carbonyl}amino)benzyl]te
Cas No.	229005-80-5
分子式	C₃₃H₃₉ClN₂O₂
分子量	531.13
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	TAK-779 是一种有效的，选择性的，非肽类 CCR5 和 CXCR3 拮抗剂，对 CCR5 的 K_i 值为 1.1 nM，同时可以有效地，选择性地抑制 R5 HIV-1，在 MAGI-CCR5 细胞中，EC₅₀ 和 EC₉₀ 值分别为 1.2 nM 和 5.7 nM。
生物活性	TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a K i of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC 50 and EC 90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells.
性状	Solid
IC50 & Target[1][2]	MIP-1α-CCR5 1 nM (IC50, in CHO/CCR5 cells) MIP-1β-CCR5
体外研究(In Vitro)	TAK-779 is a potent and selective nonpeptide antagonist of CCR5, with a Ki of 1.1 nM, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells. TAK-779 less potently blocks the binding of [I]-monocyte chemotactic protein 1 to CCR2b in CHO/CCR2b cells, with an IC50 for CCR2b of 27 nM. TAK-779 also completely inhibits the binding of [I]-RANTES to CHO/CCR5 cells with an IC50 of 1.4 nM. TAK-779 (20 nM) selectively inhibits CCR5-mediated Ca-signaling. In addition, TAK-779 shows no inhibition on X4 HIV-1 strains. TAK-779 is an antagonist of CXCR3, and inhibits the migration of T cells but not T cell proliferation. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	TAK-779 (10 mg/kg per day, s.c.) significantly prolongs the allograft survival of the rat intestinal transplantation model. TAK-779 also decreases the number of CD4 as well as CD8 T cells in spleen, blood and recipient mesenteric lymph nodes (MLN). TAK-779 (150 μg per mouse, s.c.) supppresses the development of experimental autoimmune encephalomyelitis (EAE) in myelin oligodendrocyte glycoprotein (MOG)-immunized C57BL/6 mice. TAK-779 decreases the infiltration of CXCR3 and CCR5 bearing leukocytes into the spinal cord. TAK-779 does not alter myelin oligodendrocyte glycoprotein (MOG)-specific immune responses or affect the potential of MOG-specific T cells to transfer experimental autoimmune encephalomyelitis (EAE). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Baba M, et al. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5698-703. [2]. Takama Y, et al. Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model. Transpl Immunol. 2011 Jul;25(1):49-55.

溶解度数据	In Vitro: DMSO : ≥ 25 mg/mL (47.07 mM)H₂O : 16.66 mg/mL (31.37 mM; Need ultrasonic and warming)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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