Dasatinib N-oxide (Synonyms: 达沙替尼N氧化物;达沙替尼杂质)
目录号: PL03376 纯度: ≥99%
CAS No. :910297-52-8
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中文名称
Dasatinib N-oxide
中文别名
达沙替尼 N-氧化物;3-苯基丙-2-烯-1-醇;达沙替尼N氧化物;达沙替尼-N-氧化物
英文名称
Dasatinib N-oxide
英文别名
Dasatinib N-Oxide;N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-4-oxidopiperazin-4-ium-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide;N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-4-oxido-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide (ACI)
Cas No.
910297-52-8
分子式
C22H26ClN7O3S
分子量
504.00
包装储存
4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
产品详情
Dasatinib N-oxide 是 Dasatinib 的次要代谢物。Dasatinib 是一种有效且具有口服活性的双重 Src/Bcr-Abl 抑制剂。
生物活性
Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor.
性状
Solid
体内研究(In Vivo)
Dasatinib N-oxide is the pharmacologically active metabolite after oral administration. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献
[1]. Christopher LJ, et, al. Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos. 2008 Jul;36(7):1357-64.
[2]. Furlong MT, et, al. A validated LC-MS/MS assay for the simultaneous determination of the anti-leukemic agent dasatinib and two pharmacologically active metabolites in human plasma: application to a clinical pharmacokinetic study. J Pharm Biomed Anal. 2012
溶解度数据
In Vitro: DMSO : 8.33 mg/mL (16.53 mM; ultrasonic and warming and heat to 60°C)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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