Tesevatinib (Synonyms: XL-647; EXEL-7647; KD-019)
目录号: PL03350 纯度: ≥98%
CAS No. :781613-23-8
商品编号 规格 价格 会员价 是否有货 数量
PL03350-2mg 2mg ¥2250.00 请登录
PL03350-5mg 5mg ¥4339.00 请登录
PL03350-10mg 10mg ¥7714.00 请登录
PL03350-50mg 50mg 询价 询价
PL03350-100mg 100mg 询价 询价
PL03350-10mM*1mLinDMSO 10mM*1mLinDMSO ¥5212.00 请登录
Medlife所售产品仅用于科学研究(非临床研究),非药品不可食用,不可用于人体或动物的临床诊断和治疗,我们不为个人提供产品及服务。产品COA等资料,可至下方“质量控制”中下载。
中文名称
Tesevatinib
中文别名
N-(3,4-二氯-2-氟苯基)-6-甲氧基-7-(((3aR,6aS)-2-甲基八氢环戊并[c]吡咯-5-基)甲氧基)喹唑啉-4-胺;N-(3,4-二氯-2-氟苯基)-6-甲氧基-7-[[(3AALPHA,5BETA,6AALPHA)-八氢-2-甲基环戊并[C]吡咯-5-基]甲氧基]-4-喹唑啉胺
英文名称
Tesevatinib
英文别名
XL647;Tesevatinib;XL-647;EXEL-7647;KD-019;XL 647;F6XM2TN5A1;KD019;Tesevatinib [USAN:INN];EXEL 7647;7-[[(3aS,6aR)-2-methyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-5-yl]methoxy]-N-(3,4-dichloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine;KD 019;C24H25Cl2FN4O2;GTPL7944;BCP23438;2809AH
Cas No.
781613-23-8
分子式
C24H25Cl2FN4O2
分子量
491.39
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
Tesevatinib (XL-647; EXEL-7647; KD-019) 是口服可用的多靶点酪氨酸激酶抑制剂; 抑制 EGFR,ErbB2,KDR,Flt4 和 EphB4 激酶活性的 IC50 值分别为 0.3,16,1.5,8.7,和1.4 nM。
生物活性
Tesevatinib (XL-647; EXEL-7647; KD-019) is an orally available, multi-target tyrosine kinase inhibitor; inhibits EGFR, ErbB2, KDR, Flt4 and EphB4 kinase with IC 50 s of 0.3, 16, 1.5, 8.7, and 1.4 nM.
性状
Solid
IC50 & Target[1][2]
EGFR 0.3 nM (IC50) ErbB2 16 nM (IC50
体外研究(In Vitro)
Tesevatinib (XL-647) potently inhibits the EGF/ErbB2, VEGF, and ephrin RTK families. Tesevatinib (XL-647) is a reversible and ATP competitive inhibitor. Tesevatinib (XL-647) was inactive against a panel of 10 tyrosine kinases (including the insulin and the insulin-like growth factor-1 receptor) and 55 serine-threonine kinases (including cyclin-dependent kinases, stress-activated protein kinases, and protein kinase C isoforms). Tesevatinib (XL-647) inhibits cellular proliferation and EGFR pathway activation in the erlotinib-resistant H1975 cell line that harbors a double mutation (L858R and T790M) in the EGFR gene. In A431 cells, Tesevatinib (XL-647) reduces cell viability with IC50 values of 13 nM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Tesevatinib (XL-647) shows potent and long-lived inhibition of the WT EGFR in vivo. Tesevatinib (XL-647) substantially inhibits the growth of H1975 xenograft tumors and reduces both tumor EGFR signaling and tumor vessel density. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
ClinicalTrial
参考文献
[1]. Gendreau SB, et al. Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647. Clin Cancer Res. 2007 Jun 15;13(12):3713-23.
溶解度数据
In Vitro: DMSO : 100 mg/mL (203.50 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

相关产品

更多
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2