Gemcitabine-O-Si(di-iso)-O-Mc
目录号: PL03173 纯度: ≥95%
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中文名称
Gemcitabine-O-Si(di-iso)-O-Mc
英文名称
Gemcitabine-O-Si(di-iso)-O-Mc
包装储存
4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
产品详情
Gemcitabine-O-Si(di-iso)-O-Mc 是抗体偶联药物的一部分,由嘧啶核苷类似物抗代谢药和抗肿瘤剂 Gemcitabine (HY-17026) 和 ADC linker 连接而成。
生物活性
Gemcitabine-O-Si(di-iso)-O-Mc is a drug-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent; HY-17026), linked via the ADC linker.
性状
Solid
体外研究(In Vitro)
Antibody drug conjugates (ADC) couple therapeutic monoclonal antibodies (mAb) with potent toxins through a linker that is stable within systemic circulation, but cleaves within the target cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献
[1]. Mathew C. Finniss, et al. A versatile acid-labile linker for antibody–drug conjugate. MedChemComm, Issue 9, 2014.
溶解度数据
In Vitro: DMSO : 100 mg/mL (179.00 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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