LDC4297 hydrochloride 是 CDK7 的选择性抑制剂，IC₅₀ 值为 0.13 nM。LDC4297 hydrochloride 抑制人巨细胞病毒 (HCMV) 复制，EC₅₀ 值为 24.5 nM。LDC4297 hydrochloride 具有广谱的抗病毒活性，对疱疹病毒，腺病毒，痘病毒，逆转录病毒和正粘病毒的 EC₅₀ 值为 0.02-1.21 μM。LDC4297 hydrochloride 可用于感染的研究。

LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC 50 value of 0.13 nM. LDC4297 hydrochloride inhibits human cytomegalovirus (HCMV) replication with an EC 50 value of 24.5 nM. LDC4297 hydrochloride shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC 50 values of 0.02-1.21 μM. LDC4297 hydrochloride can be used for the research of infection.

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CDK7 0.13 nM (IC50) 166v VP22-GFP 0.02 μM

LDC4297 hydrochloride (0-10 μM; 6 d) dose-dependently inhibits HCMV replication with an EC50 value of 24.5 nM.
LDC4297 hydrochloride (0-10 μM; 4 d) shows anti-proliferative activity to primary cultures of fibroblasts derived from human (HFF) with a GI50 value of 4.5 μM.
LDC4297 hydrochloride (20 μM; 12-96 h) shows anti-HCMV activity through a multifaceted mode of action that involves an interference with virus-induced Rb phosphorylation.
LDC4297 hydrochloride (0-10 μM; 7 d) shows broad antiviral activities to HCMV, GPCMV, MCMV, HVV-6A, HSV-1, HSV-2, VZV, EBV, HAdV-2, Vaccinia virus, HIV-1 (nl4-3), HIV-1 (4LIG7) and Influenza A virus with EC50 values of 0.02, 0.05, 0.07, 0.04, 0.02, 0.27, 0.06, 1.21, 0.25, 0.77, 1.04, 1.13 and 0.99 μM, respectively. has not independently confi

LDC4297 hydrochloride (100 mg/kg; p.o. once) shows promising pharmacokinetic analyses. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: CD1 mice

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

[1]. Hutterer C, et al. A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations. Antimicrob Agents Chemother. 2015 Apr;59(4):2062-71.