Mofezolac|78967-07-4|(莫苯唑酸)-陌孚医药/Medlife

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Mofezolac (Synonyms: 莫苯唑酸)

目录号: PL02471 纯度: ≥98%

CAS No. :78967-07-4

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中文名称	Mofezolac
中文别名	莫非佐酸;莫苯唑酸
英文名称	Mofezolac
英文别名	2-(3,4-Bis(4-methoxyphenyl)isoxazol-5-yl)acetic acid;[3,4-Bis-(4-methoxyphenyl)isoxazol-5-yl]-acetic acid;5-Isoxazoleacetic acid,3,4-bis(4-methoxyphenyl)-;MOFEZOLAC;[3,4-bis(4-methoxyphenyl)-1,2-oxazol-5-yl]a;3,4-Bis((4-methoxyphenyl)-5-isooxazolyl)acetic acid;3,4-Bis(4-methoxyphenyl)-5-isoxazoleacetic acid;3,4-bis(p-Methoxyphenyl)-5-isoxazoleacetic acid;Acetic acid, 3,4-bis(4-methoxyphenyl)-5-isooxazolyl-;BRN 5986171;CCRIS 4316;Mofezolac [INN];Mofezolaco;Mofezolaco [INN-Spanish];Mofezolacum;Mofezolacum [INN-Latin];N-22;UNII-RVJ0BV3H3Y;N 22;Mofezolac (TN);5-Isoxazoleacetic acid, 3,4-bis(4-methoxyphenyl)-;RVJ0BV3H3Y;C19H17NO5;(3,4-bis(4-methoxyphenyl)-5-isoxazolyl)acetic acid;[3,4-Bis-(4-me
Cas No.	78967-07-4
分子式	C₁₉H₁₇NO₅
分子量	339.34
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情	Mofezolac，一种非甾体类抗炎药 (NSAID)，是一种选择性，可逆和具有口服活性的 COX-1 抑制剂，IC₅₀ 为 1.44 nM。Mofezolac 对 COX-2 的抑制活性较弱 (IC₅₀ 为 447 nM)。Mofezolac 可缓解疼痛并具有抗炎活性。
生物活性	Mofezolac, a non-steroidal anti-inflammatory drug (NSAID), is a selective, reversible and orally active COX-1 inhibitor with an IC 50 of 1.44 nM. Mofezolac shows weak inhibitory activity on COX-2 (IC 50 of 447 nM). Mofezolac can relieve pain and has anti-inflammatory activities.
性状	Solid
IC50 & Target[1][2]	COX-1 1.44 nM (IC50) COX-2 447 nM (IC
体外研究(In Vitro)	Mofezolac inhibits platelet aggregation with an IC50 of 0.45 μM in human platelet rich plasma (hPRP) assay. Mofezolac slightly increase Bortezomib cytotoxic effect on multiple myeloma (MM) cell lines (NCI-H929 and RPMI-8226) and affects MM cell cycle and apoptosis when co-administered with the proteasome inhibitor Bortezomib. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Mofezolac (1-30 mg/kg; oral administration; once) treatment results in the suppression of writhing induced by the intraperitoneal injection of phenyl-p-benzoquinone in mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. K Goto, et al. Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice. Prostaglandins Other Lipid Mediat. 1998 Jul;56(4):245-54. [2]. Maria Laura Pati, et al. Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability. Eur J Med Chem. 2019 Feb 15;164:59-76.

溶解度数据	In Vitro: DMSO : 100 mg/mL (294.69 mM; Need ultrasonic)配制储备液

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