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Etilevodopa hydrochloride

(Synonyms: L-DOPA ethyl ester hydrochloride; Levodopa ethyl ester hydrochloride)

目录号: PL02283 纯度: ≥99%

Etilevodopa hydrochloride (L-Dopa ethyl ester hydrochloride) 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa 用于帕金森病 (PD)的相关研究。Levodopa 是多巴胺的直接前体，有助于中枢神经系统的渗透和传递多巴胺。

CAS No. :39740-30-2

商品编号	规格	价格	会员价
PL02283-5mg	5mg	¥284.00	请登录
PL02283-10mg	10mg	¥491.00	请登录
PL02283-25mg	25mg	¥982.00	请登录
PL02283-50mg	50mg	¥1645.00	请登录
PL02283-100mg	100mg	¥2645.00	请登录
PL02283-200mg	200mg	询价	询价
PL02283-500mg	500mg	询价	询价
PL02283-10mM*1mLinWater	10mM*1mLinWater	¥884.00	请登录

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中文名称	Etilevodopa hydrochloride
中文别名	L-多巴乙基酯盐酸盐
英文名称	Etilevodopa hydrochloride
英文别名	L-DOPA Ethyl Ester Hydrochloride;(S)-3,4-dihydroxyphenylalanine ethyl ester hydrochloride;Etilevodopa hydrochloride
Cas No.	39740-30-2
分子式	C₁₁H₁₆ClNO₄
分子量	261.70
包装储存	4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
详情描述	Etilevodopa hydrochloride (L-Dopa ethyl ester hydrochloride) 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa 用于帕金森病 (PD)的相关研究。Levodopa 是多巴胺的直接前体，有助于中枢神经系统的渗透和传递多巴胺。

产品详情	Etilevodopa hydrochloride (L-Dopa ethyl ester hydrochloride) 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa 用于帕金森病 (PD)的相关研究。Levodopa 是多巴胺的直接前体，有助于中枢神经系统的渗透和传递多巴胺。
生物活性	Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine.
性状	Solid
体外研究(In Vitro)	Etilevodopa (L-Dopa ethyl ester) hydrochloride passes unchanged through the stomach to the duodenum, where it is rapidly hydrolyzed by local esterases to Levodopa and ethanol, and is subsequently absorbed into the blood stream as Levodopa. Compared with standard Levodopa, Etilevodopa hydrochloride has greater solubility in the stomach, faster passage to the small intestine, and a shortened time to maximum Levodopa concentration. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
参考文献	[1]. Djaldetti R, et al. Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinsons disease: an open-label, randomized, crossover study. Clin Neuropharmacol. 2003 Nov-Dec;26(6):322-6. [2]. Blindauer K, et al. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations. Arch Neurol. 2006 Feb;63(2):210-6.

溶解度数据	In Vitro: H₂O : 125 mg/mL (477.65 mM; Need ultrasonic)配制储备液

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[1]. Djaldetti R, et al. Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinsons disease: an open-label, randomized, crossover study. Clin Neuropharmacol. 2003 Nov-Dec;26(6):322-6.
[2]. Blindauer K, et al. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations. Arch Neurol. 2006 Feb;63(2):210-6.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Etilevodopa hydrochloride

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