Bimosiamose|187269-40-5|-陌孚医药/Medlife

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Bimosiamose

目录号: PL01546 纯度: ≥98%

CAS No. :187269-40-5

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中文名称	Bimosiamose
英文名称	Bimosiamose
英文别名	[1,1'-Biphenyl]-3-aceticacid, 3',3'''-(1,6-hexanediyl)bis[6'-(a-D-mannopyranosyloxy)-;(1,1'-Biphenyl)-3-acetic acid, 3',3'''-(1,6-hexanediyl)bis(6'-(alpha-D-mannopyranosyloxy)-;(Hexane-1,6-diylbis(6'-(alpha-D-mannopyranosyloxy)biphenyl-3',3-diyl))diacetic acid;1,6-Bis(3-(3-carboxymethylphenyl)-4-(2-alpha-D-mannopyranosyloxy)phenyl)hexane;TBC 1269;TBC-1269;UNII-97B5KCW80W;Bimosiamose
Cas No.	187269-40-5
分子式	C₄₆H₅₄O₁₆
分子量	862.91
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Bimosiamose (TBC-1269) 是一种非寡糖泛-selectin 拮抗剂，对 E-selectin，P-selectin 和 L-selectin 的 IC₅₀ 分别为 88 μM，20 μM 和 86μM。Bimosiamose 具有抗炎作用。

生物活性

Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC 50 s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects.

性状

Solid

IC50 & Target[1][2]

IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)

体外研究(In Vitro)

Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72.

溶解度数据	In Vitro: DMSO : 100 mg/mL (115.89 mM; Need ultrasonic)0.1 M NaOH : 25 mg/mL (28.97 mM; ultrasonic and adjust pH to 10 with NaOH)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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